Comparison of the Femtosecond Laser and Mechanical Keratome for Laser In Situ Keratomileusis
Comparison of the Femtosecond Laser and Mechanical Keratome for Laser In Situ Keratomileusis
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DOI：
10.1001/archopht.126.11.1484
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发表时间：
2008-11-01
影响因子：
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通讯作者：
Manche, Edward E.
中科院分区：
文献类型：
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作者：
Chan, Annie;Ou, Judy;Manche, Edward E.
目的：比较随机接受飞秒激光创建皮瓣的对侧眼的临床结局（飞秒组）或机械角膜刀创建的皮瓣（机械组）在波前引导的激光原位角膜磨镶术中。设计：前瞻性，随机，比较临床研究。主要结果测量：有效性、安全性、可预测性、稳定性、角膜光学像差和低对比度视力的变化，结果：43例患者在本研究中接受了评估。术后1个月，飞秒激光组的平均（SD）等效球镜为-0.15（0.30）屈光度（D），机械组为-0.12（0.29）D（差异无统计学显著性）。术后12个月，飞秒激光组中39只眼（98%）的裸眼视力为20/20或更好，而机械组为37只眼（95%）。术后1个月（P=.55）、3个月（P =.05）、6个月（P=.33）和12个月（P=.48）时，飞秒组的高阶、球面和彗差较少，三叶形像差较多。在25%对比度下，飞秒激光组在术后1个月（P= 0.01）和6个月（P= 0.008.Conclusion：角膜磨镶术后12个月，两组的临床结局相似。
Objective: To compare clinical outcomes between fellow eyes randomized to femtosecond laser-created flaps (femtosecond group) or mechanical keratome-created flaps (mechanical group) during wavefront-guided laser in situ keratomileusis.Design: Prospective, randomized, comparative clinical study.Main Outcome Measures: Efficacy, safety, predictability, stability, changes in corneal optical aberrations, and low-contrast visual acuity before and 1 week and 1, 3, 6, and 12 months after surgery.Results: Forty-three patients underwent evaluation in this study. One month after surgery, the mean (SD) spherical equivalent was -0.15 (0.30) diopters (D) for the femtosecond group and -0.12 (0.29) D for the mechanical group (differences were not statistically significant). Twelve months after surgery, 39 eyes (98%) in the femtosecond group had uncorrected visual acuity of 20/20 or better compared with 37 (95%) in the mechanical group. The femtosecond group had fewer high-order, spherical, and coma aberrations and more trefoil aberrations than the mechanical group at 1 month (P=.55), 3 months (P=.05), 6 months (P=.33), and 12 months (P=.48) after surgery. At 25% contrast, the femtosecond group had gains at 1 month (P=.01) and 6 months (P=.008) after surgery.Conclusion: Twelve months after keratomileusis, clinical outcomes were similar for both groups.