Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics
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DOI：
10.1016/0022-510x(96)00126-8
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发表时间：
1996-10-01
影响因子：
4.4
通讯作者：
Karpati, G
中科院分区：
文献类型：
--
作者：
Stewart, JD;McKelvey, R;Karpati, G
7例糖尿病患者发生了进行性、中度、运动神经病变，而不是感觉神经病变，主要影响腿部。这符合慢性炎性脱髓鞘性多发性神经病（CIDP）的临床和电生理标准。神经活检显示各种异常，没有一个明确区分糖尿病多发性神经病和CIDP。患者接受皮质类固醇、硫唑嘌呤、血浆置换和静脉注射免疫球蛋白联合治疗;所有患者均大幅改善。我们认为CIDP可能伪装成异常严重和进行性糖尿病远端对称性多发性神经病。认识糖尿病患者的CIDP很重要，因为与糖尿病多发性神经病不同，CIDP是可治疗的。
Seven diabetic patients developed a progressive, moderately severe, motor rather than sensory neuropathy predominantly affecting the legs. This met clinical and electrophysiological criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). Nerve biopsies showed a variety of abnormalities, none of which clearly distinguished between diabetic polyneuropathy and CIDP. The patients were treated with combinations of corticosteroids, azathioprine, plasmapheresis and intravenous immune globulin; all improved substantially. We believe that CIDP may masquerade as unusually severe and progressive diabetic distal symmetric polyneuropathy. It is important to recognize CIDP in diabetics because, unlike diabetic polyneuropathy, CIDP is treatable.