Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
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DOI：
10.1038/s41467-018-07345-0
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发表时间：
2018-11-28
影响因子：
16.6
通讯作者：
Kato N
中科院分区：
文献类型：
--
作者：
Takeuchi F;Akiyama M;Matoba N;Katsuya T;Nakatochi M;Tabara Y;Narita A;Saw WY;Moon S;Spracklen CN;Chai JF;Kim YJ;Zhang L;Wang C;Li H;Li H;Wu JY;Dorajoo R;Nierenberg JL;Wang YX;He J;Bennett DA;Takahashi A;Momozawa Y;Hirata M;Matsuda K;Rakugi H;Nakashima E;Isono M;Shirota M;Hozawa A;Ichihara S;Matsubara T;Yamamoto K;Kohara K;Igase M;Han S;Gordon-Larsen P;Huang W;Lee NR;Adair LS;Hwang MY;Lee J;Chee ML;Sabanayagam C;Zhao W;Liu J;Reilly DF;Sun L;Huo S;Edwards TL;Long J;Chang LC;Chen CH;Yuan JM;Koh WP;Friedlander Y;Kelly TN;Bin Wei W;Xu L;Cai H;Xiang YB;Lin K;Clarke R;Walters RG;Millwood IY;Li L;Chambers JC;Kooner JS;Elliott P;van der Harst P;International Genomics of Blood Pressure (iGEN-BP) Consortium;Chen Z;Sasaki M;Shu XO;Jonas JB;He J;Heng CK;Chen YT;Zheng W;Lin X;Teo YY;Tai ES;Cheng CY;Wong TY;Sim X;Mohlke KL;Yamamoto M;Kim BJ;Miki T;Nabika T;Yokota M;Kamatani Y;Kubo M;Kato N
血压 (BP) 是心血管疾病的主要危险因素，已知有 200 多个与 BP 相关的基因位点。在这里，我们主要针对东亚人进行了多阶段全基因组关联研究（最大 N = 289,038），并对东亚人和欧洲人进行了荟萃分析。我们报告了 19 个新的遗传位点和祖先特异性 BP 变异，符合共同的祖先特异性变异关联模型。在 10 个独特的位点，不同的非罕见祖先特异性变体共定位在同一连锁不平衡块内，尽管种族群体之间的代理共享变体的影响显着不一致。收缩压和舒张压的因果变异效应大小的全基因组跨种族相关性分别为 0.898 和 0.851。一些特定于祖先的关联信号也受到选择性扫描的影响。我们的结果为共同祖先特异性变异和自然选择在复杂性状（如血压）的种族差异中的作用提供了新的证据。血压 (BP) 是心血管疾病的主要危险因素，已知有 200 多个与 BP 相关的基因位点。在这里，作者对东亚人的 BP 进行了发现 GWAS，并对东亚人和欧洲人进行了荟萃分析，并报告了血统特异性的 BP SNP 和选择信号。
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
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影响因子：
30.8
作者：
Liu C;Kraja AT;Smith JA;Brody JA;Franceschini N;Bis JC;Rice K;Morrison AC;Lu Y;Weiss S;Guo X;Palmas W;Martin LW;Chen YD;Surendran P;Drenos F;Cook JP;Auer PL;Chu AY;Giri A;Zhao W;Jakobsdottir J;Lin LA;Stafford JM;Amin N;Mei H;Yao J;Voorman A;CHD Exome+ Consortium;ExomeBP Consortium;GoT2DGenes Consortium;T2D-GENES Consortium;Larson MG;Grove ML;Smith AV;Hwang SJ;Chen H;Huan T;Kosova G;Stitziel NO;Kathiresan S;Samani N;Schunkert H;Deloukas P;Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia;Li M;Fuchsberger C;Pattaro C;Gorski M;CKDGen Consortium;Kooperberg C;Papanicolaou GJ;Rossouw JE;Faul JD;Kardia SL;Bouchard C;Raffel LJ;Uitterlinden AG;Franco OH;Vasan RS;O'Donnell CJ;Taylor KD;Liu K;Bottinger EP;Gottesman O;Daw EW;Giulianini F;Ganesh S;Salfati E;Harris TB;Launer LJ;Dörr M;Felix SB;Rettig R;Völzke H;Kim E;Lee WJ;Lee IT;Sheu WH;Tsosie KS;Edwards DR;Liu Y;Correa A;Weir DR;Völker U;Ridker PM;Boerwinkle E;Gudnason V;Reiner AP;van Duijn CM;Borecki IB;Edwards TL;Chakravarti A;Rotter JI;Psaty BM;Loos RJ;Fornage M;Ehret GB;Newton-Cheh C;Levy D;Chasman DI
通讯作者：
Chasman DI
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
影响因子：
7.7
作者：
Scott RA;Scott LJ;Mägi R;Marullo L;Gaulton KJ;Kaakinen M;Pervjakova N;Pers TH;Johnson AD;Eicher JD;Jackson AU;Ferreira T;Lee Y;Ma C;Steinthorsdottir V;Thorleifsson G;Qi L;Van Zuydam NR;Mahajan A;Chen H;Almgren P;Voight BF;Grallert H;Müller-Nurasyid M;Ried JS;Rayner NW;Robertson N;Karssen LC;van Leeuwen EM;Willems SM;Fuchsberger C;Kwan P;Teslovich TM;Chanda P;Li M;Lu Y;Dina C;Thuillier D;Yengo L;Jiang L;Sparso T;Kestler HA;Chheda H;Eisele L;Gustafsson S;Frånberg M;Strawbridge RJ;Benediktsson R;Hreidarsson AB;Kong A;Sigurðsson G;Kerrison ND;Luan J;Liang L;Meitinger T;Roden M;Thorand B;Esko T;Mihailov E;Fox C;Liu CT;Rybin D;Isomaa B;Lyssenko V;Tuomi T;Couper DJ;Pankow JS;Grarup N;Have CT;Jørgensen ME;Jørgensen T;Linneberg A;Cornelis MC;van Dam RM;Hunter DJ;Kraft P;Sun Q;Edkins S;Owen KR;Perry JRB;Wood AR;Zeggini E;Tajes-Fernandes J;Abecasis GR;Bonnycastle LL;Chines PS;Stringham HM;Koistinen HA;Kinnunen L;Sennblad B;Mühleisen TW;Nöthen MM;Pechlivanis S;Baldassarre D;Gertow K;Humphries SE;Tremoli E;Klopp N;Meyer J;Steinbach G;Wennauer R;Eriksson JG;Mӓnnistö S;Peltonen L;Tikkanen E;Charpentier G;Eury E;Lobbens S;Gigante B;Leander K;McLeod O;Bottinger EP;Gottesman O;Ruderfer D;Blüher M;Kovacs P;Tonjes A;Maruthur NM;Scapoli C;Erbel R;Jöckel KH;Moebus S;de Faire U;Hamsten A;Stumvoll M;Deloukas P;Donnelly PJ;Frayling TM;Hattersley AT;Ripatti S;Salomaa V;Pedersen NL;Boehm BO;Bergman RN;Collins FS;Mohlke KL;Tuomilehto J;Hansen T;Pedersen O;Barroso I;Lannfelt L;Ingelsson E;Lind L;Lindgren CM;Cauchi S;Froguel P;Loos RJF;Balkau B;Boeing H;Franks PW;Barricarte Gurrea A;Palli D;van der Schouw YT;Altshuler D;Groop LC;Langenberg C;Wareham NJ;Sijbrands E;van Duijn CM;Florez JC;Meigs JB;Boerwinkle E;Gieger C;Strauch K;Metspalu A;Morris AD;Palmer CNA;Hu FB;Thorsteinsdottir U;Stefansson K;Dupuis J;Morris AP;Boehnke M;McCarthy MI;Prokopenko I;DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
通讯作者：
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
30.8
作者：
Finucane HK;Bulik-Sullivan B;Gusev A;Trynka G;Reshef Y;Loh PR;Anttila V;Xu H;Zang C;Farh K;Ripke S;Day FR;ReproGen Consortium;Schizophrenia Working Group of the Psychiatric Genomics Consortium;RACI Consortium;Purcell S;Stahl E;Lindstrom S;Perry JR;Okada Y;Raychaudhuri S;Daly MJ;Patterson N;Neale BM;Price AL
通讯作者：
Price AL