COMPARATIVE IMMUNOGENICITY STUDIES ON EPSTEIN-BARR VIRUS MEMBRANE ANTIGEN (MA) GP340 WITH NOVEL ADJUVANTS IN MICE, RABBITS, AND COTTON-TOP TAMARINS
COMPARATIVE IMMUNOGENICITY STUDIES ON EPSTEIN-BARR VIRUS MEMBRANE ANTIGEN (MA) GP340 WITH NOVEL ADJUVANTS IN MICE, RABBITS, AND COTTON-TOP TAMARINS
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DOI：
10.1002/jmv.1890130310
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发表时间：
1984-01-01
影响因子：
12.7
通讯作者：
NORTH, JR
中科院分区：
文献类型：
--
作者：
MORGAN, AJ;EPSTEIN, MA;NORTH, JR
使用有或没有额外佐剂的各种注射途径，比较了用少量EB [Epstein-Barr]病毒膜抗原糖蛋白gp 340（掺入人工脂质体）免疫小鼠、兔和棉顶绢毛猴的有效性。含有gp 340的脂质体在腹膜内或静脉内给药后产生特异性高滴度抗体;向脂质体中加入脂质A导致应答显著增强。通过上述方法产生的抗体是病毒中和性的并且特异性结合gp 340。这些发现表明了与用于预防EB病毒感染的原型疫苗一起使用的有利方法。
The effectiveness of immunization of mice, rabbits and cotton-top tamarins with small amounts of EB [Epstein-Barr] virus membrane antigen glycoprotein gp340, incorporated into artificial liposomes, was compared using various routes of injection with or without additional adjuvants. Liposomes containing gp340 gave specific high titer antibodies after i.p. or i.v. administration; the addition of lipid A to the liposomes resulted in a significant enhancement of the response. Antibodies generated by the above procedure were virus neutralizing and bound gp340 specifically. These findings indicate an advantageous approach for use with a prototype vaccine for the prevention of EB virus infection.