Longitudinal trajectories of cholesterol from midlife through late life according to apolipoprotein E allele status.
Longitudinal trajectories of cholesterol from midlife through late life according to apolipoprotein E allele status.
复制标题
DOI：
10.3390/ijerph111010663
复制
发表时间：
2014-10-16
影响因子：
--
通讯作者：
Fardo DW
中科院分区：
文献类型：
--
作者：
Downer B;Estus S;Katsumata Y;Fardo DW
背景资料：先前的研究表明，总胆固醇水平在青年和中年期间随着年龄的增长而增加，并在以后的生活中随着年龄的增长而下降。这是由于饮食，身体成分，药物使用，身体活动和激素水平的变化。在目前的研究中，我们利用来自心脏研究原始队列的数据来确定载脂蛋白E（APOE）的变化，一种参与调节胆固醇稳态的基因，是否会影响总胆固醇，HDL胆固醇和总：HDL胆固醇比率从中年到晚年的轨迹。研究方法：从中年到晚年的胆固醇轨迹使用广义加性混合模型和混合效应回归模型进行建模。结果如下：与APOE e3和APOE e4+受试者相比，APOE e2+受试者从中年到晚年的总胆固醇水平较低，HDL胆固醇水平较高，总：HDL胆固醇比值较低。根据性别和降胆固醇药物的使用，还检测到寿命胆固醇轨迹的统计学显著差异。结论：这项研究的结果提供了证据，证明APOE的变化改变了从中年到晚年的血清胆固醇的轨迹。为了在整个生命周期内有效地改变胆固醇，重要的是要考虑APOE等位基因状态。
Background: Previous research indicates that total cholesterol levels increase with age during young adulthood and middle age and decline with age later in life. This is attributed to changes in diet, body composition, medication use, physical activity, and hormone levels. In the current study we utilized data from the Framingham Heart Study Original Cohort to determine if variations in apolipoprotein E (APOE), a gene involved in regulating cholesterol homeostasis, influence trajectories of total cholesterol, HDL cholesterol, and total: HDL cholesterol ratio from midlife through late life. Methods: Cholesterol trajectories from midlife through late life were modeled using generalized additive mixed models and mixed-effects regression models. Results: APOE e2+ subjects had lower total cholesterol levels, higher HDL cholesterol levels, and lower total: HDL cholesterol ratios from midlife to late life compared to APOE e3 and APOE e4+ subjects. Statistically significant differences in life span cholesterol trajectories according to gender and use of cholesterol-lowering medications were also detected. Conclusion: The findings from this research provide evidence that variations in APOE modify trajectories of serum cholesterol from midlife to late life. In order to efficiently modify cholesterol through the life span, it is important to take into account APOE allele status.
登录
查看更多内容
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
37.8
作者：
Albert, Michelle A.;Glynn, Robert J.;Ridker, Paul M.
通讯作者：
Ridker, Paul M.
影响因子：
8.7
作者：
de Beer, F;Stalenhoef, AFH;Smelt, AHM
通讯作者：
Smelt, AHM
影响因子：
3.6
作者：
Babischkin, JS;Grimes, RW;Albrecht, ED
通讯作者：
Albrecht, ED
影响因子：
7
作者：
Donini, LM;Savina, C;Cannella, C
通讯作者：
Cannella, C