[Fatal acute liver failure: a rare complication of exertion-induced heat stroke].
[Fatal acute liver failure: a rare complication of exertion-induced heat stroke].
复制标题
[致命的急性肝衰竭：劳累性中暑的罕见并发症]。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
D. Grimaud
中科院分区：
文献类型：
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作者：
C. Ichai;J. Ciais;H. Hyvernat;Y. Labib;P. Fabiani;D. Grimaud
肝损伤是劳动性中暑的常见并发症。然而，严重的急性不可逆肝功能障碍很少相关。持续性小叶中心肝细胞坏死而无任何再生仍然是非常罕见的。我们报告一例劳力性中暑后发生致命的急性肝功能衰竭。尽管进行了常规对症治疗，特别是主动降温，患者在入院后6天发生多器官衰竭伴脑死亡。在这种情况下，长期使用抗精神病药物和抗胆碱能药物可能被认为是一个诱发因素。
Liver injury is a well-known complication of exertional heat stroke. However severe acute irreversible liver dysfunction is rarely associated. Persistent centrolobular hepatocellular necrosis without any regeneration remains very uncommon. We report a case of fatal acute liver failure occurring after exertional heat stroke. Despite the conventional symptomatic treatment, especially active cooling, the patient experienced multiple organ failure with brain death 6 days after his admission. In this case, a chronic treatment with neuroleptic and anticholinergic agents may be considered as a predisposing factor.