Inhibins, activins, and follistatin in the aging female and male
Inhibins, activins, and follistatin in the aging female and male
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DOI：
10.1055/s-2004-831896
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发表时间：
2004-08-01
影响因子：
2.7
通讯作者：
Santoro, N
中科院分区：
文献类型：
--
作者：
Hurwitz, JM;Santoro, N
二聚体抑制素、激活素和卵泡抑素(FS)最初都是调节卵泡刺激素(FSH)分泌的生殖内分泌激素。然而，这种模式在当前医学证据的重压下得到了扩展。激活素似乎在生殖和非生殖组织中发挥着中枢自分泌/旁分泌作用。抑制素和FS在激活素信号转导中都具有重要的逆调节功能。随着生殖年龄的增长，抑制素B随着卵泡池的减少而下降，并干扰生殖中期正常月经周期的动态。FSH分泌抑制素的丧失似乎是导致月经周期缩短和生殖年末某些激素不可预测的内分泌事件的始动因素。这也可能与生殖年龄导致的生育力下降有关。在男性中，抑制素B是性腺功能的一个很好的标志，随着年龄的增长，抑制素B的下降反映了两性性腺储备的减少。循环激活素随着年龄的增长而增加，但它对女性和男性生殖的影响尚不清楚。在男性和女性中，FS似乎没有随着年龄的增长而发生很大的变化。这一微妙平衡的调节三联体中与年龄相关的波动会影响生殖能力和时序老化的后遗症。阐明负责这些激素作用的分子途径可能会使它们与目前在衰老中的概念角色更紧密地结合在一起。
Dimeric inhibins, activins, and follistatin (FS) were all initially characterized as reproductive endocrine hormones that regulate follicle-stimulating hormone (FSH) secretion. This model, however, has expanded under the weight of current medical evidence. Activin appears to play a central auto/paracrine role in reproductive and nonreproductive tissues. Inhibin and FS each have important counterregulatory functions in activin signaling. With reproductive aging, inhibin B declines along with the follicular pool and disturbs the dynamics of the normal menstrual cycle of midreproductive age. The loss of inhibin restraint of FSH secretion appears to be the initiating endocrine event that leads to menstrual cycle shortening and some of the hormonal unpredictability of the late reproductive years. It may also be related to the decline in fertility that occurs in reproductive aging. In men, inhibin B is an excellent marker for gonadal competence, and the decline of inhibin B with age reflects decreased gonadal reserve in both sexes. Circulating activin increases with aging, but its effect on reproduction in women and men is not clear. FS does not appear to change greatly with aging in men or women. The age-related fluctuations in this delicately balanced regulatory triad influence reproductive capacity and the sequelae of chronological aging. Elucidation of the molecular pathways responsible for the action of these hormones may allow closer integration with their current conceptual roles in aging.