Hippocampal cytotoxic lesion effects on species-typical behaviours in mice
Hippocampal cytotoxic lesion effects on species-typical behaviours in mice
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DOI：
10.1016/s0166-4328(01)00401-6
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发表时间：
2002-05-14
影响因子：
2.7
通讯作者：
Rawlins, JNP
中科院分区：
文献类型：
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作者：
Deacon, RMJ;Croucher, A;Rawlins, JNP
海马损伤对大鼠行为的影响已被广泛记录。然而，不能假设为大鼠开发的范式可以直接转移到小鼠；这两个物种的行为在许多方面不同。目前，老鼠是目标基因操作的首选物种。其中一些项目旨在调节海马体功能。因此，目前的研究旨在提供小鼠任务中选择性、细胞毒性海马病变的行为概况。这些病变消除了从基地外的来源囤积食物，并减少了从笼子内的管中转移食物颗粒的倾向（挖洞）。在有孔板和开阔的场地，受损小鼠的定向探索（直立和低头）减少，但没有运动活动，当盖子被移除时，探索其家庭笼子边缘的次数减少。巢的建造也受到了影响。这些影响不是由于大运动障碍，因为正式的测试显示在协调或力量方面没有缺陷。有情绪变化的建议，尽管一个更一致的发现是，受损小鼠在新环境中往往较慢地启动行为，这可能与我们观察到的其他缺陷一致。这些结果可能有助于解释许多针对海马体的遗传操作，以及诱导海马体病理的神经退行性疾病。(C) 2002 Elsevier Science B.V.版权所有
The behavioural effects of hippocampal lesions have been extensively documented in rats. However, paradigms developed for rats cannot be assumed to transfer straightforwardly to mice; the behaviour of the two species differs in many respects. Mice are currently the species of choice for targeted genetic manipulations. A number of these programs aim to modulate hippocampal function. The present studies were therefore designed to provide a behavioural profile of selective, cytotoxic hippocampal lesions in tasks appropriate for mice. The lesions abolished food hoarding from a source outside the home base, and reduced the tendency to displace food pellets from a tube inside the home cage (burrowing). Lesioned mice showed reductions of directed exploration (rearing and head dipping), but not locomotor activity, in a holeboard and open field, and explored the edges of their home cages less when the lids were removed. Nest construction was also impaired. These effects were not due to gross motor impairments, as formal tests revealed no deficiencies in co-ordination or strength. There were suggestions of changes in emotionality, although a more consistent finding was that lesioned mice were often slower to initiate behaviour in novel surroundings, which may be congruent with the other deficits we observed. These results may aid interpretation of the many genetic manipulations that target the hippocampus, and of neurodegenerative conditions that induce hippocampal pathology. (C) 2002 Elsevier Science B.V. All rights reserved.