A gamma‐aminobutyric‐acid‐mediated inhibition of neurones in the nucleus tractus solitarius of the cat.
A gamma‐aminobutyric‐acid‐mediated inhibition of neurones in the nucleus tractus solitarius of the cat.
复制标题
γ-氨基丁酸介导的猫孤束核神经元抑制作用。
DOI：
10.1113/jphysiol.1987.sp016788
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Shepheard
中科院分区：
文献类型：
--
作者：
J. Bennett;P. McWilliam;S. Shepheard
1. Extracellular recordings were made from 123 synaptically activated neurones in the nucleus tractus solitarius of the chloralose‐anaesthetized cat. 2. Ninety‐one neurones were activated by electrical stimulation of cardiac or pulmonary vagal branches and thirty‐two by stimulation of the aortic nerve. 3. Ionophoretic application of GABA abolished or markedly reduced the evoked or spontaneous activity of each neurone tested. These inhibitory effects were antagonized by the simultaneous ionophoretic application of bicuculline. 4. Glycine inhibited the evoked activity of 60% of neurones tested. This inhibition could be antagonized by the simultaneous application of strychnine. 5. Application of bicuculline alone increased the evoked or spontaneous activity of a large proportion of the neurones; strychnine alone had no significant effect on the evoked or spontaneous activity of the neurones. 6. These results are consistent with the hypothesis that GABA acts as an inhibitory transmitter substance within the nucleus tractus solitarius.
