Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
复制标题
DOI：
10.4049/jimmunol.145.10.3442
复制
发表时间：
1990-11
影响因子：
4.4
通讯作者：
C. Ferrari;A. Penna;A. Bertoletti;A. Valli;A. Antoni;T. Giuberti;A. Cavalli;M. Petit;F. Fiaccadori
中科院分区：
文献类型：
--
作者：
C. Ferrari;A. Penna;A. Bertoletti;A. Valli;A. Antoni;T. Giuberti;A. Cavalli;M. Petit;F. Fiaccadori
前瞻性地分析了21例急性自限性乙肝病毒感染者外周血单个核细胞(PBMC)对包膜、核心和e抗原的增殖反应，并与慢性乙肝病毒感染者和不同水平的病毒复制(即HBeAg或抗-HBe阳性)和肝损害(即慢性活动性肝炎或慢性无症状携带者)的反应进行了比较。我们的结果表明：1)发生自限性急性肝炎的患者显示出强烈的PBMC对乙肝核心抗原和HBeAg的反应，作为T细胞激活的表达；2)可检测到的淋巴细胞对乙肝病毒核衣壳抗原的反应与乙肝病毒包膜抗原的清除暂时相关；3)在慢性乙肝感染患者中，T细胞对乙肝核心抗原和HBeAg的反应水平显著低于急性感染期间；4)在急慢性乙肝病毒感染中，T细胞对乙肝病毒包膜抗原的敏感性通常是无法检测到的，当可检测到的时候，可检测到的表达是短暂的和低水平的。这些结果可能反映了与疾病演变和病毒清除相关的致病免疫事件。
The proliferative response of PBMC to hepatitis B virus (HBV) envelope, core, and e Ag was analyzed prospectively in 21 patients with acute self-limited HBV infection and compared with the response of patients with chronic HBV infection and different levels of HBV replication (i.e., hepatitis e Ag (HBeAg)- or anti-HBe-positive) and liver damage (i.e., chronic active hepatitis or chronic asymptomatic carriers). Our results indicate that: 1) HBV-infected subjects who develop a self-limited acute hepatitis show a vigorous PBMC response to hepatitis B core Ag and HBeAg, as expression of T cell activation; 2) appearance of a detectable lymphocyte response to HBV nucleocapsid Ag is temporally associated with the clearance of HBV envelope Ag; 3) in patients with chronic HBV infection the level of T cell responsiveness to hepatitis B core Ag and to HBeAg is significantly lower than that observed during acute infection; 4) T cell sensitization to HBV envelope Ag in acute and chronic HBV infection is usually undetectable and when measurable is expressed transiently and at low levels. These results may reflect immune events of pathogenetic relevance with respect to evolution of disease and viral clearance.