Central command-related increases in blood velocity of anterior cerebral artery and prefrontal oxygenation at the onset of voluntary tapping
Central command-related increases in blood velocity of anterior cerebral artery and prefrontal oxygenation at the onset of voluntary tapping
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自愿敲击开始时大脑前动脉血流速度和前额叶氧合与中枢命令相关的增加
DOI：
10.1152/ajpheart.00062.2021
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Scott A Smith
中科院分区：
文献类型：
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作者：
Kanji Matsukawa;Ryota Asahara;Minami Uzumaki;Yoshiki Hashiguchi;Kei Ishii;Jijia Wang;Scott A Smith
大脑前动脉(ACA)主要供应血液到额叶，包括前额皮质。我们的实验室报告，只要运动是随意开始的，在运动开始前和运动开始时，前额叶氧合血红蛋白浓度(Oxy-Hb)就会增加。此外，前额叶氧合的增加似乎与运动强度和肌肉质量无关。如果是这样的话，ACA的平均血流速度(ACABV)应该随着“非常轻微的运动努力”而增加，同时伴随着运动前和最初额叶Oxy-Hb的增加。本研究旨在检测12名受试者在任意或线索手指敲击时ACA和额叶前部Oxy-Hb的ACABV和血管传导指数(ACAVCI)的反应，这是一项Borg分级为7(中位数)的活动。任意起搏时，ACABV随着ACAVCI的升高而增加(14 ± 9%)。同样，前额叶Oxy-Hb在敲击开始时升高，其时间进程类似于ACABV。67%的受试者ACABV的初始变化与额叶OXY-Hb呈显著正相关，滞后时间为2 S，而75%的受试者ACABV与前额氧合血红蛋白呈显著的线性正相关。当通过提示强制开始敲击时，与任意开始相比，ACABV、ACAVCI和前额叶Oxy-Hb的初始增加延迟和钝化。因此，只要任意开始敲击，只要开始敲击，ACA血管床就会发生活跃的血管扩张，并有助于立即增加血流量和前额氧合。新与注意：大脑前动脉血流速度和血管电导指数以及前额叶含氧血红蛋白浓度在手指敲击开始时都会增加，只要任意开始敲击，就会在开始敲击后立即达到峰值。67%-75%的受试者ACABV和前额Oxy-Hb的升高之间存在显著的正相关和线性回归。ACA血管床的主动血管扩张在任意敲击开始时发生，并有助于增加ACABV和前额叶氧合。
The anterior cerebral artery (ACA) supplies blood predominantly to the frontal lobe including the prefrontal cortex. Our laboratory reported that prefrontal oxygenated-hemoglobin concentration (Oxy-Hb) increased before and at exercise onset, as long as exercise is arbitrarily started. Moreover, the increased prefrontal oxygenation seems independent of both exercise intensity and muscle mass. If so, mean blood velocity of the ACA (ACABV) should increase with “very light motor effort,” concomitantly with the preexercise and initial increase in prefrontal Oxy-Hb. This study aimed to examine the responses in ACABVand vascular conductance index (ACAVCI) of the ACA as well as prefrontal Oxy-Hb during arbitrary or cued finger tapping in 12 subjects, an activity with a Borg scale perceived exertion rating of 7 (median). With arbitrary start, ACABVincreased at tapping onset (14 ± 9%) via an elevation in ACAVCI. Likewise, prefrontal Oxy-Hb increased at the onset of tapping with a time course resembling that of ACABV. A positive cross correlation between the initial changes in ACABVand prefrontal Oxy-Hb was found significant in 67% of subjects, having a time lag of 2 s, whereas a positive linear regression between them was significant in 75% of subjects. When tapping was forced to start by cue, the initial increases in ACABV, ACAVCI, and prefrontal Oxy-Hb were delayed and blunted as compared with an arbitrary start. Thus, active vasodilatation of the ACA vascular bed occurs at tapping onset, as long as tapping is arbitrarily started, and contributes to immediate increases in blood flow and prefrontal oxygenation.NEW & NOTEWORTHYAnterior cerebral artery blood velocity and vascular conductance index along with prefrontal oxygenated-hemoglobin concentration all increased at the onset of finger tapping, peaking immediately after tapping onset, as long as tapping was arbitrarily started. Positive cross correlation and linear regression between the increases in ACABVand prefrontal Oxy-Hb were significant in 67%–75% of subjects. Active vasodilatation of the ACA vascular bed occurs with arbitrary tapping onset and contributes to increased ACABVand prefrontal oxygenation.