Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.
Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.
复制标题
海绵体内给予亚硝酸钠作为勃起药物疗法。
DOI：
10.1139/y10-032
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发表时间：
2010
影响因子：
2.1
通讯作者：
Kadowitz,PhilipJ
中科院分区：
文献类型：
--
作者：
Lasker,GeorgeF;Matt,ChristopherJ;BadejoJr,AdelekeM;Casey,DavidB;Dhaliwal,JasdeepS;Murthy,SubramanyamN;Kadowitz,PhilipJ
据报道，亚硝酸钠（NaNO 2）可以作为一氧化氮（NO）的储存形式，具有有益的药理作用。本研究旨在探讨亚硝酸钠对大鼠勃起功能的影响。海绵体内（i.c.）注射NaNO 2可使i.c.血压和全身动脉压降低。在增加i.c.方面，NaNO 2的效力比硝普钠低1000倍。压力增加i.c.一氧化氮合酶（NOS）激动剂N-硝基-L-精氨酸甲酯（L-NAME）可抑制NaNO 2引起的血压升高。增加了i.c.黄嘌呤氧化还原酶抑制剂别嘌呤醇不改变对NaNO 2的反应。体循环动脉压响应于i.c.注射NaNO 2可被别嘌呤醇减弱，并且通过增加yl-NAME或保持不变。这些数据表明，在大鼠海绵体和全身血管床中，NaNO 2通过不同的机制转化为血管活性NO。目前的数据表明，转换的NaNO 2血管活性NO介导的NOS在阴茎海绵体和黄嘌呤氧化还原酶在全身血管床的大鼠。这些数据表明，NaNO 2可以作为NO供体，增加大鼠的勃起活动。
It has been reported that sodium nitrite (NaNO2) can act as a storage form of nitric oxide (NO) that can have beneficial pharmacologic actions. The present study was undertaken to investigate the effects of NaNO2on erectile function in the rat. The intracavernosal (i.c.) injection of NaNO2produced dose-related increases in i.c. pressure and decreases in systemic arterial pressure. NaNO2was 1000-fold less potent than sodium nitroprusside in increasing i.c. pressure. Increases in i.c. pressure in response to NaNO2were attenuated by the nitric oxide synthase (NOS) inhibitorN-nitro-l-arginine methyl ester (l-NAME). The increases in i.c. pressure in response to NaNO2were not altered by the xanthine oxidoreductase inhibitor allopurinol. The decreases in systemic arterial pressure in response to i.c. injections of NaNO2were attenuated by allopurinol and were either unchanged or increased byl-NAME. These data suggest that NaNO2is converted to vasoactive NO in the corpora cavernosum and systemic vascular bed of the rat by different mechanisms. The present data suggest that the conversion of NaNO2to vasoactive NO is mediated by NOS in the corpora cavernosum and by xanthine oxidoreductase in the systemic vascular bed of the rat. These data show NaNO2can serve as a NO donor that increases erectile activity in the rat.