The role of retinal pigment epithelium in the involution of subretinal neovascularization.
The role of retinal pigment epithelium in the involution of subretinal neovascularization.
复制标题
DOI：
--
复制
发表时间：
1986-11
影响因子：
4.4
通讯作者：
H. Miller;B. Miller;S. Ryan
中科院分区：
文献类型：
--
作者：
H. Miller;B. Miller;S. Ryan
研究了激光诱导实验性视网膜下新生血管形成（SRN）周围的血管外环境，该环境是新生血管膜从早期渗漏阶段到晚期消退阶段的演变过程。当血管造影上出现可见渗漏的最初迹象时，新形成的血管在布鲁赫膜破裂周围的视网膜下腔中扩散，液体在视网膜下腔中积聚，并且视网膜色素上皮（RPE）细胞在新形成的血管周围以乳头状模式增殖； RPE 增殖始于激光损伤边缘未受损的细胞。随着进一步成熟，RPE 继续包裹视网膜下血管。这种 RPE 增殖与包膜血管和感觉视网膜之间的液体消失以及血管造影期间荧光素渗漏的逐渐停止有关。在复旧过程结束时，当新生血管膜不再表现出任何渗漏时，发现视网膜下血管被RPE细胞紧密包裹，并且没有液体将它们与感觉视网膜分开。作者的结果表明，随着可见荧光素渗漏的停止，新生血管膜随着成熟而退化，这是 RPE 增殖的结果，它紧紧包裹着新形成的血管，并可能吸收先前积累的视网膜下液，并防止其在视网膜下腔中进一步积累。
The extravascular milieu around laser-induced experimental subretinal neovascularization (SRN) was studied during the evolution of the neovascular membrane from its early leaky stage to its late involuted stage. When the first signs of visible leakage appeared on angiography, newly formed vessels were spread in the subretinal space around the break in Bruch's membrane, fluid was accumulating in the subretinal space, and retinal pigment epithelial (RPE) cells were proliferating in a papillary pattern around the newly formed vessels; the RPE proliferation began with the undamaged cells at the edges of the laser injury. With further maturation, the RPE continued to envelope the subretinal vessels. This RPE proliferation was associated with the disappearance of fluid between the enveloped vessels and the sensory retina, and the gradual cessation of fluorescein leakage during angiography. At the end of the involution process, when the neovascular membrane no longer demonstrated any leakage, the subretinal vessels were found to be tightly enveloped by RPE cells, and no fluid separated them from the sensory retina. The authors' results suggest that involution of the neovascular membrane with maturation, as demonstrated by the cessation of visible fluorescein leakage, is the result of RPE proliferation that tightly envelopes the newly formed vessels and probably resorbs the previously accumulated subretinal fluid, as well as preventing its further accumulation in the subretinal space.