New roles for galectins in brain tumors--from prognostic markers to therapeutic targets.
New roles for galectins in brain tumors--from prognostic markers to therapeutic targets.
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半乳糖凝集素在脑肿瘤中的新作用——从预后标志物到治疗靶点。
DOI：
10.1111/j.1750-3639.2005.tb00507.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Baum,LindaG
中科院分区：
文献类型：
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作者：
Stillman,BriannaN;Mischel,PaulS;Baum,LindaG
尽管在诊断和治疗方面取得了进展，但脑肿瘤仍然是35岁以下患者癌症相关死亡的主要原因，这表明需要更好的预后和治疗靶点。半乳糖凝集素是哺乳动物碳水化合物结合蛋白的一个家族，参与许多对肿瘤存活和扩散重要的过程，包括增殖、凋亡、转录调节、细胞内信号传导、细胞粘附和细胞迁移。几种半乳糖凝集素在人脑中表达，其中许多半乳糖凝集素在肿瘤进展期间表现出改变的表达。因此，半乳糖凝集素及其调控的功能是脑癌诊断和治疗的潜在靶点。本文综述了半乳糖凝集素在癌症中的作用，特别是半乳糖凝集素在脑癌中的发展领域。
Despite advances in diagnosis and treatment, brain tumors continue to be the leading cause of cancer‐related death in patients under 35 years of age, demonstrating the need for better prognostic and therapeutic targets. Galectins, a family of mammalian carbohydrate binding proteins, are involved in many processes important for tumor survival and dissemination, including proliferation, apoptosis, transcriptional regulation, intracellular signaling, cell adhesion, and cell migration. Several galectins are expressed in human brain, with many galectins demonstrating altered expression during tumor progression. Thus, galectins and the functions regulated by this family of proteins are potential targets for the diagnosis and treatment of brain cancer. This review highlights the roles of galectins in cancer and specifically, the developing field of galectins in brain cancer.