Clinical applications of DNase I, a genetic marker already used for forensic identification
Clinical applications of DNase I, a genetic marker already used for forensic identification
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DOI：
10.1016/j.legalmed.2004.10.008
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发表时间：
2005-07-01
期刊：
影响因子：
1.5
通讯作者：
Kishi, Koichiro
中科院分区：
文献类型：
--
作者：
Yasuda, Toshihiro;Kawai, Yasuyuki;Kishi, Koichiro
本文主要综述了脱氧核糖核酸酶I （DNase I）的临床应用。人类DNA酶I在蛋白质和DNA水平上都表现出多态性，因此可能是法医实践中最好的生化标记之一。在临床上，血清DNase I活性可作为早期检测急性心肌梗死和短暂性心肌缺血的一种新的诊断指标。此外，DNase 1基因被认为是胃癌、大肠癌和心肌梗死的易感基因之一。在过去的十年中，自从发现其基因多态性用于法医目的以来，对dna酶I的研究已扩展到临床应用。2005爱思唯尔爱尔兰有限公司版权所有。
This review primarily summarizes the clinical applications of deoxyribonuclease I (DNase I). Human DNase I exhibits polymorphism at both the protein and DNA level, and thus is potentially one of the best biochemical markers for forensic practice. Clinically, DNase I activity in serum can be used as a novel diagnostic marker for the early detection of acute myocardial infarction and transient myocardial ischemia. Furthermore, the DNase I gene is considered to be one of the susceptibility genes for gastric and colorectal carcinoma, and myocardial infarction. Over the last decade since the discovery of the utility of its genetic polymorphism for forensic purposes, research on DNase I has expanded into clinical applications. (c) 2005 Elsevier Ireland Ltd. All rights reserved.