S100A4 mRNA is a Diagnostic and Prognostic Marker in Pancreatic Carcinoma
S100A4 mRNA is a Diagnostic and Prognostic Marker in Pancreatic Carcinoma
复制标题
DOI：
10.1007/s11605-009-0978-4
复制
发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Tanaka, Masao
中科院分区：
文献类型：
--
作者：
Ikenaga, Naoki;Ohuchida, Kenoki;Tanaka, Masao
目的探讨S100A4基因在胰腺癌组织中的表达及其临床意义。材料与方法采用激光显微切割法获取10例胰腺癌组织中的浸润性导管癌(IDC)细胞、20例胰腺癌组织中的乳头状黏液瘤细胞(IPMN)和20例正常胰腺组织中的正常导管细胞。结果87例胰腺癌组织中S100A4的表达水平明显高于胰腺癌组织(P=0.002)和正常导管细胞(P
Objective The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer.Materials and Methods We obtained invasive ductal carcinoma (IDC) cells from ten lesions, intraductal papillary mucinous neoplasm (IPMN) cells from 20 lesions, and normal ductal cells from 20 normal pancreatic tissues by laser microdissection of frozen tissues. S100A4 expression was examined in the microdissected cells and in formalin-fixed paraffin-embedded (FFPE) samples of 87 pancreatic cancers by quantitative reverse transcription-polymerase chain reaction.Results IDC cells expressed higher levels of S100A4 than IPMN cells (P=0.002) and normal ductal cells (P