Parenteral Vaccination Can Be an Effective Means of Inducing Protective Mucosal Responses
Parenteral Vaccination Can Be an Effective Means of Inducing Protective Mucosal Responses
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DOI：
10.1128/cvi.00214-16
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发表时间：
2016-06-01
影响因子：
--
通讯作者：
Freytag, Lucy C.
中科院分区：
文献类型：
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作者：
Clements, John D.;Freytag, Lucy C.
目前疫苗开发的范例是，非复制型疫苗经肠道外递送无法在粘膜组织中诱导免疫反应。然而，临床和实验数据都对这一概念提出了挑战，许多研究表明，肠外疫苗接种后诱导粘膜免疫反应并不罕见，事实上，可能对肠外疫苗提供的粘膜感染保护作用显著。虽然这种现象背后的机制尚不清楚，但认识到非肠道疫苗接种可以是诱导保护性粘膜反应的有效手段是一种范式转变，并有可能改变疫苗的设计和交付方式。
The current paradigm in vaccine development is that nonreplicating vaccines delivered parenterally fail to induce immune responses in mucosal tissues. However, both clinical and experimental data have challenged this concept, and numerous studies have shown that induction of mucosal immune responses after parenteral vaccination is not a rare occurrence and might, in fact, significantly contribute to the protection against mucosal infections afforded by parenteral vaccines. While the mechanisms underlying this phenomenon are not well understood, the realization that parenteral vaccination can be an effective means of inducing protective mucosal responses is paradigm-shifting and has potential to transform the way vaccines are designed and delivered.