Tracking the re-emergence of epidemic chikungunya virus in Indonesia
Tracking the re-emergence of epidemic chikungunya virus in Indonesia
复制标题
DOI：
10.1016/j.trstmh.2004.03.013
复制
发表时间：
2005-02-01
影响因子：
2.2
通讯作者：
Corwin, AL
中科院分区：
文献类型：
--
作者：
Laras, K;Sukri, NC;Corwin, AL
2001年9月至2003年3月，在印度尼西亚境内基孔肯雅热流行活动中断近20年之后，在全国各地确定了24次可能的基孔肯雅病病因暴发。13例暴发报告仅基于临床观察，11例经血清学/病毒学方法证实。介绍了茂物和勿加西两次调查暴发的详细流行病学概况。采用ELISA法筛选人血清中IgM和IgG抗chik抗体。此外，还尝试了逆转录酶PCR和病毒分离来鉴定病毒。茂物病例的平均年龄为37.18岁，勿加西病例的平均年龄为33.20岁。虽然观察到受疫情影响的家庭在地理上分组在村庄内，但没有明显的病例聚集性。茂物和勿加西的袭击率分别为2.8/1000和6.7/1000。这两次暴发都是在埃及伊蚊和白纹伊蚊密度增加后的雨季开始的。(C) 2004年皇家热带医学与卫生学会。Elsevier Ltd.出版。版权所有。
Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serotogical/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 18 years in Bogor and 33 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.