PERIPARTURIENT HYPOCALCEMIA IN COWS - EFFECTS ON PERIPHERAL-BLOOD NEUTROPHIL AND LYMPHOCYTE FUNCTION
PERIPARTURIENT HYPOCALCEMIA IN COWS - EFFECTS ON PERIPHERAL-BLOOD NEUTROPHIL AND LYMPHOCYTE FUNCTION
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DOI：
10.3168/jds.s0022-0302(89)79223-7
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发表时间：
1989-05-01
影响因子：
3.5
通讯作者：
GOFF, JP
中科院分区：
文献类型：
--
作者：
KEHRLI, ME;GOFF, JP
围产期奶牛很容易受到乳房内感染和临床乳腺炎的影响。流行病学证据表明，产妇麻痹（乳热）会大大增加乳腺炎的风险，尽管因果关系尚未确定。在本实验中，研究了分娩时低钙血症对奶牛免疫状态的影响。研究了 10 头健康经产荷斯坦奶牛产前饲喂高钙日粮诱导分娩时低钙血症对奶牛免疫状态的影响。十头健康的多产荷斯坦奶牛在产前喂食高钙饮食，以诱发分娩时低钙血症。其中五头奶牛接受肌内甲状旁腺激素（粗合成 N 末端 1-34）以预防分娩时低钙血症。在围产期（从产前 6 周到产后 5 周）期间确定低钙血症对各种中性粒细胞和淋巴细胞功能的影响。所有奶牛在分娩前后的几周内都表现出免疫细胞功能的严重丧失。低钙血症或产后麻痹的发生并不会加剧免疫细胞功能障碍。这意味着观察到的低钙血症程度对围产期奶牛的中性粒细胞和淋巴细胞功能没有大的或不可逆的影响。
Periparturient dairy cows are quite susceptible to intrammamry infections and clinical mastitis. Epidemiologic evidence indicates that parturient paresis (milk fever) greatly increases the risk of mastitis, although a causal relationship has not been established. In the present experiment the effects of hypocalcemia at parturition on the immune status of dairy cows were investigated. Ten healthy, multiparous Holstein cows were fed a high Ca diet prepartum to induce hypocalcemi at parturition on the immune status of dairy cows were investigated. Ten healthy, multiparous Holstein cows were fed a high Ca diet prepartum to induce hypocalcemia at parturition. Five of these cows received intramuscular parathyroid hormone (crude synthetic N-terminus 1-34) to prevent hypocalcemia at parturition. Effects of hypocalcemia on various neutrophil and lymphocyte functions were determined during the periparturient period, ranging and from 6 wk prepartum to 5 wk postpartum. All cows exhibited severe loss of immune cell function in the weeks surrounding parturition. Hypocalcemia or the development of parturient paresis did not exacerbate the immune cell dysfunction. This implies that the degree of hypocalcemia observed did not have a large or irreversible influence on neutrophil and lymphocyte function in periparturient cows.