Accelerated Growth in Early Life and Obesity in Preschool Chilean Children
Accelerated Growth in Early Life and Obesity in Preschool Chilean Children
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DOI：
10.1038/oby.2009.37
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发表时间：
2009-08-01
期刊：
影响因子：
6.9
通讯作者：
Uauy, Ricardo
中科院分区：
文献类型：
--
作者：
Kain, Juliana;Corvalan, Camila;Uauy, Ricardo
智利儿童肥胖率很高。本文的目的是比较正常（N），超重（OW）和肥胖（OB）的5岁奥尔兹从0到5岁的体重指数的增长特点，并探讨一些产前因素对这些增长模式的影响。该研究对1,089名出生体重>2,500 g的5岁奥尔兹进行了回顾性队列研究。从9次（0-36个月）的记录中获得体重和身高;在52和60个月时，我们测量了它们。在60个月时，儿童被分类为N，OW和OB。在每个年龄，BMI和BMI的z评分（BMI Z）差异进行了比较。还探讨了出生体重、孕前BMI和产前变量（体重增加、吸烟、糖尿病和先兆子痫）对N和OB之间BMI Z差异的影响。N组未观察到肥胖反弹（AR），但OW组和OB组分别在52个月和24个月时发生了类似的情况。N和OB之间的BMI Z差异从出生开始就很显著，但在6-12个月和36-52个月之间最大。通过出生体重、孕前BMI和产前变量进行的额外调整降低了前24个月的BMI Z差异，在此年龄后几乎没有影响。转型后国家的OB儿童出生后立即加速生长，比AR早得多。产前因素对肥胖获得的影响最多可持续到2岁，尽管此后BMI的增加与产后变量更相关。
In Chile, childhood obesity rates are high. The purpose of this article is to compare BMI growth characteristics of normal (N), overweight (OW), and obese (OB) 5-year olds from 0 to 5 years and explore the influence of some prenatal factors on these patterns of growth. The study was done on a retrospective cohort of 1,089 5-year olds with birth weight >2,500 g. Weight and height were obtained from records at nine occasions (0-36 months); at 52 and 60 months, we measured them. At 60 months, children were classified as N, OW, and OB. At each age, BMI and z-score of BMI (BMI Z) differences were compared among groups. The influence of birth weight, pre-pregnancy BMI, and prenatal variables (weight gain, smoking, and presence of diabetes and preeclampsia) on BMI Z differences between N and OB was also explored. Adiposity rebound (AR) was not observed for the N, although for the OW, it occurred similar to 52 months and for the OB at similar to 24 months. BMI Z differences between N and OB were significant from birth, but were greatest between 6-12 and 36-52 months. Additional adjustment by birth weight, pre-pregnancy BMI, and prenatal variables decreased the BMI Z differences for the first 24 months with virtually no effect after this age. Accelerated growth in OB children from post-transition countries occurs immediately after birth, much earlier than the AR. The influence of prenatal factors on adiposity acquisition may extend at most until 2 years of life, although BMI gains thereafter are more related to postnatal variables.