Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates
Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates
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DOI：
10.1097/00006534-200005000-00005
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发表时间：
2000-05-01
影响因子：
3.6
通讯作者：
Otley, CC
中科院分区：
文献类型：
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作者：
Gassner, HG;Sherris, DA;Otley, CC
外科医生不断寻求获得最美观的疤痕。决定皮肤疤痕最终外观的主要因素是愈合阶段作用在伤口边缘的张力。自 1892 年 Theodor Kocher 率先将皮肤切口与兰格线对齐以来，试图克服闭合张力的手术技术已成为标准。然而，目前还没有任何治疗方法可以最大限度地减少潜在的肌肉收缩，这是造成这种紧张的主要原因。 A 型肉毒杆菌毒素是一种强效药物，局部注射时会产生暂时性肌肉麻痹。事实证明，它可以安全有效地治疗多种疾病，包括面部皱纹多动症。这项随机、双盲、安慰剂对照灵长类动物研究的目的是研究单次注射 A 型肉毒杆菌毒素对改善皮肤疤痕美容外观的功效。在 sis 灵长类动物前额的两侧进行对称的标准化切除。半额头被随机分为 A 型肉毒杆菌毒素治疗侧和安慰剂注射侧。由三名不知情的面部外科医生组成的小组在术后 3 个月评估了成熟疤痕的外观。用a肉毒杆菌毒素固定的伤口，评级为显着！外观优于对照伤口 (p < 0.01)。组织学检查证实所有疤痕均已成熟。失明了。梅奥诊所目前正在进行随机、安慰剂对照的人体临床试验。
Surgeons have constantly sought to achieve the most aesthetic scar. A major factor determining the final cosmetic appearance of a cutaneous scar is the tension acting on the wound edges during the healing phase. Since Theodor Kocher pioneered the alignment of skin incisions with Langer's lines in 1892, surgical techniques that attempt to overcome closing tension have become standard. Yet, no treatment has been available to minimize underlying muscle contractions, which are the major cause of this tension. Botulinum toxin A is a potent drug that produces temporary muscular paralysis when injected locally. It has proven to be safe and effective in the treatment of a variety of disorders, including hyperkinetic facial lines. The objective of this randomized, double-blind, placebo-controlled primate study was to investigate the efficacy of a single injection of botulinum toxin A to improve the cosmetic appearance of cutaneous scars. Symmetric pairs of standardized excisions were performed on either side of the forehead of sis primates. The half foreheads were randomized to the botulinum toxin A treatment side versus the placebo injection side. A panel of three blinded facial surgeons assessed the cosmetic appearance of the mature scars 3 months postoperatively. The wounds that had been immobilized with botulinum toxin a were rated as significantly! better in appearance than the control wounds (p < 0.01). Histologic examination confirmed that all scars were mature. Blinded. randomized, placebo-controlled human clinical trials are presently underway at the Mayo Clinic.