HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION *
HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION *
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DOI：
10.1111/j.1751-1097.1990.tb01807.x
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发表时间：
1990-09
影响因子：
3.3
通讯作者：
Diwu Zhenjun;J. Lown
中科院分区：
文献类型：
--
作者：
Diwu Zhenjun;J. Lown
摘要/ Abstract摘要：Hypocrellins A和B是从寄生真菌Hypocrella bambuase (B. et Br) sacc中分离得到的色素。在中华人民共和国（prc）和斯里兰卡分别发现的Shiraia bambusicola P. Heen。这些制剂属于苝类醌类色素的总称，作为传统药用制剂有着悠久的历史，特别是在中国，近年来它们具有显著的光敏性，并开始了探索性的研究。这一努力使人们认识到hypocrellins在肿瘤光动力治疗方面的潜力。本文综述了邻苯二甲酸甲酯及其衍生物的化学和光物理性质，以及迄今为止在分子、细胞和体内水平上的光敏性研究，并展望了它们作为PDT制剂的前景。
Abstract— Hypocrellins A and B are pigments which are isolated from parasitic fungi Hypocrella bambuase (B. et Br) sacc. and Shiraia bambusicola P. Heen found in the People's Republic of China (P.R.C.) and Sri Lanka respectively. These agents, which belong to the general class of perylene quinonoid pigments, have a long history as traditional medicinal agents especially in the P.R.C. Recently their marked photosensitizing properties have been established and exploratory studies initiated. This effort has led to the realization of the potential of the hypocrellins for the photodynamic therapy of tumors. The review summarizes the chemical and photophysical properties of the hypocrellins and their derivatives as well as studies on photosensitization to date at the molecular, cellular and in vivo levels, and their prospects as PDT agents.