MECHANICAL EXCITATION OF COMPLEX STAPES MOTION IN GUINEA PIGS
MECHANICAL EXCITATION OF COMPLEX STAPES MOTION IN GUINEA PIGS
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豚鼠复杂镫骨运动的机械激励
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
A. Huber
中科院分区：
文献类型：
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作者：
A. Eiber;C. Breuninger;Damien Sequeira;A. Huber
正如在许多研究中所观察到的，镫骨在声刺激下的自然振动模式揭示了依赖于激励频率的复杂运动模式。而对于低频率的运动主要是活塞式的，可以发现显着的摇摆较高的频率。耳蜗流体通过活塞状运动和沿踏板的短轴和长轴的两个沿着旋转运动机械地排出。旋转分量不产生耳蜗流体的净体积通量，因此，它们对听觉的影响仍然是一个悬而未决的问题。为了研究耳蜗对镫骨底板复杂运动的反应，在麻醉豚鼠的镫骨上机械地施加不同的振动模式。建立了一个测试台，以定位的主题，致动器和激光多普勒测振仪可调的微操作器。设计了一种三轴压电驱动器，并通过耦合杆将其耦合到手术准备好的豚鼠的镫骨头。为了捕捉有效的运动镫骨三维激光多普勒测振仪。任意镫骨运动的激励过程包括识别和测量阶段，以确定换能器行为和耳蜗对所施加运动的响应的电生理测量。镫骨的空间速度和耳蜗电位的重复换能器激活的同时捕获的数据采集系统进行适当的后处理。驱动任意运动模式的任务比经典的一维考虑产生更高的复杂性。该设置使得能够在耳蜗电图中进行调查，其中镫骨的活塞和摇摆样运动的量不同。
As observed in many studies the natural vibration pattern of the stapes on acoustic stimulation reveals a complex motion pattern dependent on the frequency of excitation. Whereas for low frequencies the motion is predominantly piston-like, significant rocking can be found for higher frequencies. The cochlea fluid is mechanically exited by the piston-like motion and two rotational movements along the short and long axis of the footplate. The rotational components produce no net volume flux of the cochlea fluid and, therefore, their influence on the hearing sensation is still an open question. To investigate the response of the cochlea on complex motion of the stapes footplate, different vibration pattern on the stapes have been mechanically applied in anesthetized guinea pigs. A test rig was built to position the subject, an actuator and a Laser Doppler Vibrometer adjustable by micro manipulators. A three-axis piezoelectric actuator has been designed and coupled to the stapes head of the surgically prepared guinea pig by a coupling rod. For capturing the effective motion of the stapes three-dimensional laser Doppler vibrometry was applied. The excitation procedure for arbitrary stapes motion consists of both an identification and a measurement phase to determine the transducer behavior and the electrophysiological measurements of the cochlea response on the applied motion. Spatial velocity of stapes and cochlea potentials on repeated transducer activation are captured simultaneously by the data acquisition system for appropriate post-processing. The task of driving arbitrary motion patterns yields a much higher complexity than classical one-dimensional consideration. The setup enables investigations in electrocochleography with different amounts of piston and rocking-like motions of the stapes.