TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures
TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures
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大鼠口面部结构中的 TRPC1、TRPC3 和 TRPC4
DOI：
10.1159/000477665
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发表时间：
2017
影响因子：
2.7
通讯作者：
Ichikawa Hiroyuki
中科院分区：
文献类型：
--
作者：
Fujita Masatoshi;Sato Tadasu;Yajima Takehiro;Masaki Eiji;Ichikawa Hiroyuki
瞬时受体电位阳离子通道（transient receptor potential cationchannel subfamily C，TRPC）是一种非选择性的单价阳离子通道，控制Ca 2+内流.在这项研究中，TRPC 1，TRPC 3，和TRPC 4的免疫组织化学进行大鼠口腔和颅面结构，以阐明其在周边的分布和功能。在三叉神经节（TG），56.1%，84.1%和68.3%的感觉神经元的TRPC 1，TRPC 3和TRPC 4的免疫反应（IR），分别。双重免疫荧光法显示，小到中等大小的TG神经元共表达TRPCs和降钙素基因相关肽。在上级颈神经节，所有交感神经元显示TRPC 1和TRPC 3免疫反应。下颂神经节、舌和腮腺中的副交感神经元为TRPC 1、TRPC 3和TRPC 4 IR。味觉和嗅觉细胞也为TRPC 1、TRPC 3和/或TRPC 4 IR。在肌肉组织中，运动终板表达TRPC 1和TRPC 4免疫反应性。TRPC可能与口腔和颅面结构中的感觉、自主和运动功能相关。
TRPC (transient receptor potential cation channel subfamily C) members are nonselective monovalent cation channels and control Ca 2+ inflow. In this study, immunohistochemistry for TRPC1, TRPC3, and TRPC4 was performed on rat oral and craniofacial structures to elucidate their distribution and function in the peripheries. In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively. A double immunofluorescence method revealed that small to medium-sized TG neurons co-expressed TRPCs and calcitonin gene-related peptide. In the superior cervical ganglion, all sympathetic neurons showed TRPC1 and TRPC3 immunoreactivity. Parasympathetic neurons in the submandibular ganglion, tongue, and parotid gland were TRPC1, TRPC3, and TRPC4 IR. Gustatory and olfactory cells were also IR for TRPC1, TRPC3, and/or TRPC4. In the musculature, motor endplates expressed TRPC1 and TRPC4 immunoreactivity. It is likely that TRPCs are associated with sensory, autonomic, and motor functions in oral and craniofacial structures.