Anticarbohydrate antibodies as markers of inflammatory bowel disease in a Central European cohort
Anticarbohydrate antibodies as markers of inflammatory bowel disease in a Central European cohort
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DOI：
10.1097/meg.0b013e32832f5c7e
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发表时间：
2010-02-01
影响因子：
2.1
通讯作者：
Lukas, Milan
中科院分区：
文献类型：
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作者：
Malickova, Karin;Lakatos, Peter L.;Lukas, Milan
背景：本研究探讨中欧炎症性肠病(IBD)患者血清中抗几丁糖苷糖类抗体(ACCA)、抗层粘连蛋白糖类抗体(ALCA)和抗甘露糖苷类糖类抗体(AMCA)在其中的作用。用酶联免疫吸附试验检测ACCA、ALCA、AMCA和抗酿酒酵母抗体(GASCA)对CD诊断的敏感性(67%)，其次是AMCA(31%)、ACCA(27%)和ALCA(25%)。四种检测方法中至少有一种阳性，可使CD抗体检测的总体敏感性提高到85.5%。CD患者发病年龄越小，采血前病程越长，其血清GASKA平均水平越高(P<0.05)。
Background The study discusses the role of antichitobioside carbohydrate antibody (ACCA), antilaminaribioside carbohydrate antibodies (ALCA), and antimannobioside carbohydrate antibodies (AMCA) in Central European patients with inflammatory bowel disease (IBD).Patients and methods Twohundred and seventy-two serum samples were used - 116 Crohn's disease (CD), 84 ulcerative colitis, and 72 healthy control samples. All samples were evaluated using enzyme-linked immunosorbent assay for the following four anticarbohydrate assays: ACCA, ALCA, AMCA, and anti-Saccharomyces cerevisiae antibodies (gASCA).Results gASCA antibodies showed the highest sensitivity (67%) for a CD diagnosis, followed by AMCA (31%), ACCA (27%), and ALCA (25%). Positivity of at least one of the four assays increased the overall sensitivity of antibody testing in CD up to 85.5%. Mean serum gASCA levels were significantly higher in CD patients who were younger at diagnosis and had a longer disease duration before blood sampling (P