THALAMIC CONNECTIVITY OF THE 2ND SOMATOSENSORY AREA AND NEIGHBORING SOMATOSENSORY FIELDS OF THE LATERAL SULCUS OF THE MACAQUE
THALAMIC CONNECTIVITY OF THE 2ND SOMATOSENSORY AREA AND NEIGHBORING SOMATOSENSORY FIELDS OF THE LATERAL SULCUS OF THE MACAQUE
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DOI：
10.1002/cne.902520305
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发表时间：
1986-10-15
影响因子：
2.5
通讯作者：
MURRAY, EA
中科院分区：
文献类型：
--
作者：
FRIEDMAN, DP;MURRAY, EA
用氚化氨基酸和辣根过氧化物酶（HRP）对猕猴外侧沟及其周围躯体野的丘脑-皮质关系进行了研究。特别注意的是，第二体感区（S2），其连接也通过丘脑同位素注射和逆行变性进行了研究。研究表明，S2的主要丘脑输入来自丘脑腹后下核（VPI），而不是像之前报道的那样，来自腹后外侧核（VPLc）的尾侧分裂。在将同位素或HRP少量注射到S2的手代表中后，仅标记VPI。注射剂量越大，包括更多的身体部位，VPI标记越重，VPLc、中央外侧核（CL）和后核（Po）标记越分散。此外，少量同位素注入VPLc不会导致S2的标记，除非注射部位也涉及VPI，并且S2的消融导致VPI的细胞丢失。S2中涉及不同身体部位的注射的比较表明VPI内的躯体位置安排，使得躯干和下肢表示位于后外侧，手和手臂表示位于前内侧。投射到S2的头、脸和口内结构的丘脑代表的位置可能在腹后内侧核（VPM）中。丘脑的颗粒（IG）和非颗粒（Id）区和岛后区（Ri）各自接收来自位于丘脑腹后缘的各种核团的输入。IG从上膝状体-界膜复合体（SG-Li）接收最大的输入，并从Po（内侧膝状体N的大细胞分裂）接收额外的输入。（MGmc）、VPI和内侧枕（Pulm）。Id从基底腹内侧核接收其最重的输入。(VMb)，具有来自VPI、Po、SG-Li、MGmc和Pulm的附加输入。Ri从Po接收其最重的输入，另外的输入来自SG-Li、MGmc、Pulm，可能还有VPI。区域7 b接收来自Pulm的输入，Pulm是枕的口部，外侧后神经，内侧背侧神经，和腹外侧核的尾侧部。这些结果表明，躯体皮层领域，除了那些包括第一体感区，每个接收输入从丘脑核团的阵列，而不是只有一个，和个别丘脑体感中继核团每个项目到一个以上的皮层领域。
The thalamocortical relations of the somatic fields in and around the lateral sulcus of the macaque were studied following cortical injections of tritiated amino acids and horseradish peroxidase (HRP). Special attention was paid to the second somatosensory area (S2), the connections of which were also studied by means of thalamic isotope injections and retrograde degeneration. S2 was shown to receive its major thalamic input from the ventroposterior inferior thalamic nucleus (VPI) and not, as previously reported, from the caudual division of the ventroposterior lateral nucleus (VPLc). Following small injections of isotope or HRP into the hand representation of S2, only VPI was labeled. Larger injections, which included the respresentations of more body parts, led to heavy label in VPI, with scattered label in VPLc, the central lateral nucleus (CL), and the posterior nucleus (Po). In addition, small isotope injections into VPLc did not result in label in S2 unless VPI was also involed in the injection site, and ablations of S2 led to cell loss in VPI. Comparison of injections involving different body parts in S2 suggested a somatotopic arrangement within VPI such that the trunk and lower limb representations are located posterolaterally and the hand and arm representations anteromedially. The location of the thalamic representations of the head, face, and intraoral structures that project to S2 may be in the ventroposterior medial nucleus (VPM). The granular (Ig) and dysgranular (Id) fields of the insula and the retroinsular field (Ri) each receive inputs from a variety of nuclei located at the posteroventral border of the thalamus. Ig receives its heaviest input from the suprageniculate-limitans complex (SG-Li), with additional inputs from Po, the magnocellular division of the medial geniculate n. (MGmc), VPI, and the medial pulvinar (Pulm). Id receives its heaviest input from the basal ventromedial n. (VMb), with additional inputs from VPI, Po, SG-Li, MGmc, and Pulm. Ri receives its heaviest input from Po, with additional input from SG-Li, MGmc, Pulm, and perhaps VPI. Area 7b receives its input from Pulm, the oral division of the pulvinar, the lateral posterior n., the medial dorsal n., and the caudal division of the ventrolateral n. These results indicate that the somatic cortical fields, except for those comprising the first somatosensory area, each receive inputs from an array of thalamic nuclei, rather than just one, and that individual thalamic somatosensory relay nuclei each project to more than one cortical field.