Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets
Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets
复制标题
低钾右旋糖酐溶液对油酸致仔猪急性肺损伤后急性肾损伤的保护作用
DOI：
10.3760/cma.j.issn.0366-6999.2012.17.023
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发表时间：
2012-09-05
影响因子：
6.1
通讯作者：
Li Rong-shan
中科院分区：
文献类型：
--
作者：
Wu Rui-ping;Liang Xiu-bin;Li Rong-shan
背景低钾右旋糖苷(LPD)溶液可减轻急性肺损伤(ALI)。然而，LPD液治疗ALI继发的急性肾损伤尚未见报道。方法12只右心房注射油酸(OA)致ALI的动物随机分为两组：生理盐水对照组(n=6)和LPD组(n=6)。注射前1h耳缘静脉注射LPD溶液12.5ml/kg。结果所有动物均能存活，肾脏组织病理损伤较轻。平均动脉压(MAP)、肌酐和肾损害评分在两组间无显著差异。与安慰剂组相比，LPD组在ALI后6h的大部分观察点的气体交换参数((347.0+/-12.6)mm Hgvs(284.3+/-11.3)mm Hg，P
Background Low potassium dextran (LPD) solution can attenuate acute lung injury (ALI). However, LPD solution for treating acute kidney injury secondary to ALI has not been reported. The present study was performed to examine the renoprotective effect of LPD solution in ALI induced by oleic acid (OA) in piglets.Methods Twelve animals that suffered an ALI induced by administration of OA into the right atrium were divided into two groups: the placebo group (n=6) pretreated with normal saline and the LPD group (n=6), pretreated with LPD solution. LPD solution was injected intravenously at a dose of 12.5 ml/kg via the auricular vein 1 hour before OA injection.Results All animals survived the experiments with mild histopathological injury to the kidney. There were no significant differences in mean arterial pressure (MAP), creatinin and renal damage scores between the two groups. Compared with the placebo group, the LPD group had better gas exchange parameters at most of the observation points ((347.0 +/- 12.6) mmHg vs. (284.3 +/- 11.3) mmHg at 6 hours after ALI, P