Aromatic Heterocycles as Activating Groups for Asymmetric Conjugate Addition Reactions. Enantioselective Copper-Catalyzed Reduction of 2-Alkenylheteroarenes
Aromatic Heterocycles as Activating Groups for Asymmetric Conjugate Addition Reactions. Enantioselective Copper-Catalyzed Reduction of 2-Alkenylheteroarenes
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DOI：
10.1021/ja904365h
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发表时间：
2009-08-05
影响因子：
15
通讯作者：
Lam, Hon Wai
中科院分区：
文献类型：
--
作者：
Rupnicki, Leszek;Saxena, Aakarsh;Lam, Hon Wai
手性铜氢化物催化的多功能性已被证明，通过开发高度对映选择性的1，4-还原2-烯基杂芳烃，底物，很少被认为是不对称共轭加成反应。唑类和吖嗪类都是这一过程的有效活化基团。
The versatility of chiral copper hydride catalysis has been demonstrated through development of highly enantioselective 1,4-reductions of 2-alkenytheteroarenes, substrates that have been rarely considered for asymmetric conjugate addition reactions. Both azoles and azines serve as efficient activating groups for this process.