MATERNAL OCCUPATIONAL EXPOSURE AND CONGENITAL-MALFORMATIONS
MATERNAL OCCUPATIONAL EXPOSURE AND CONGENITAL-MALFORMATIONS
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DOI：
10.5271/sjweh.1613
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发表时间：
1992-02-01
影响因子：
6.3
通讯作者：
GOUJARD, J
中科院分区：
文献类型：
--
作者：
CORDIER, S;HA, MC;GOUJARD, J
进行了一项病例对照研究，以评估与孕妇怀孕前和怀孕期间职业接触有关的先天畸形风险。在15家妇产科医院确定的325例重大畸形和325例正常（出生时）参考纳入研究。由一名工业卫生学家对从母亲访谈中获得的职业史进行盲法审查，评估是否存在化学品暴露和暴露的可能性。结果表明，口裂患儿的母亲在怀孕期间更经常接触溶剂[比值比（OR）7.9，90%置信区间（90%CI）1.8-44.9]，并且更经常从事清洁工工作（4例，无参考）。消化系统异常（OR 11.9，90% CI 2.0-149）和多种异常（OR 4.5，90% CI 1.4-16.9）也与工作中的溶剂职业暴露有关。当考虑到母亲年龄、居住地区和社会经济地位的差异时，这些结果没有修改。
A case-referent study was conducted to assess the risk of congenital malformations in relation to maternal occupational exposure before and during pregnancy. Three hundred and twenty-five cases of major malformations and 325 normal (at birth) referents identified in 15 maternity hospitals were included in the study. The occupational history obtained from an interview of the mother was blindly reviewed by an industrial hygienist who assessed the presence of chemical exposure and the probability of exposure. The results suggested that mothers of the case children with oral clefts were more often exposed to solvents during pregnancy [odds ratio (OR) 7.9, 90% confidence interval (90% CI) 1.8-44.9] and worked more often as cleaners (four cases, no referents). Digestive anomalies (OR 11.9, 90% CI 2.0-149) and multiple anomalies (OR 4.5, 90% CI 1.4-16.9) were also associated with occupational exposure to solvents at work. These results were not modified when differences in maternal age, area of residence, and socioeconomic status were taken into account.