Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar
Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar
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DOI：
10.1016/j.jaad.2006.10.018
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发表时间：
2007-11-01
影响因子：
13.8
通讯作者：
Kishimoto, Saburo
中科院分区：
文献类型：
--
作者：
Morihara, Kiyoshi;Takenaka, Hideya;Kishimoto, Saburo
我们报告一例原发性皮肤间变性大细胞淋巴瘤，表现为溃疡周围广泛的红斑。溃疡的皮肤活检显示cd30阳性非典型淋巴细胞遍布真皮层，免疫染色表明这些细胞产生血管内皮生长因子，这是一种有效的血管生成刺激。红斑的皮肤活检显示丰富的新生血管，这可能与血管内皮生长因子有关。
We present a case of primary cutaneous anaplastic large cell lymphoma manifesting with widespread erythema around an ulcer. Skin biopsy from the ulcer showed CD30-positive atypical lymphocytes throughout the dermis, and immunostaining demonstrated that these cells produced vascular endothelial growth factor, a potent stimulus for, angiogenesis. Skin biopsy from the erythema revealed rich neovascularization, which was probably associated with vascular endothelial growth factor.