Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis
Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis
复制标题
多位点聚环糊精吸附剂结合血液透析去除蛋白质结合的尿毒症毒素
DOI：
10.1016/j.carbpol.2020.116665
复制
发表时间：
2020-11-01
影响因子：
11.2
通讯作者：
Jia, Lingyun
中科院分区：
文献类型：
--
作者：
Li, Jingyu;Han, Lulu;Jia, Lingyun
蛋白结合尿毒症毒素(PBUT)在血液透析治疗的慢性肾脏疾病患者血液中积聚的发生率很高。由于各种PBUT与相应结合蛋白的强相互作用和复杂的血液背景，开发高效、选择性和去除各种PBUT的吸附剂仍然具有挑战性。在此，我们报道了具有多个吸附位置的聚环糊精吸附剂用于去除血浆中的PBUT。与聚α-环糊精和聚γ-环糊精相比，聚β-环糊精(P-βCD)具有最好的吸附性能和对甲酚硫酸盐(PCS)的最大结合容量(263 mg g(-1))。与血液透析相结合，透析液中加入β-环糊精，可通过吸附一次过的方式去除血浆中96%的PCS。此外，可以有效地去除共存于血浆中的各种PBUT，表现出对PβCD的高浓度PBUT吸附性能。我们期待PCD吸附剂与血液透析疗法相结合，有望成为临床去除PBUT的一种有前途的方法。
Accumulation of protein-bound uremic toxins (PBUTs) has a high incidence in the blood of hemodialysis-treated patients with chronic kidney disease. Development of adsorbent for the high-efficient, selective, and removal of various PBUTs is still challenging because of their strong interactions to the corresponding binding proteins and the complex blood background. Herein, we reported poly-cyclodextrins adsorbents with multi adsorption-sites for PBUTs removal from plasma. Compared to poly-alpha-cyclodextrin and poly-gamma-cyclodextrin, poly-beta-cyclodextrin (P beta CD) showed the best adsorption capability and the maximum p-cresol sulfate (PCS, a model PBUT) binding capacity of P beta CD (263 mg g(-1)). Combining with hemodialysis, P beta CD adsorbents added into the dialysate can remove 96 % PCS in the plasma via adsorbent once-through mode. Additionally, various PBUTs co-exsiting in the plasma could be effectively removed, exhibiting high-concentrition PBUT adsorption property of P beta CD. We expect that the PCD adsorbents combining with hemodialysis therapy may become a promising potential for clinical PBUT removal.