The Role of Promoter-Associated Histone Acetylation of Haem Oxygenase-1 (HO-1) and Giberellic Acid-Stimulated Like-1 (GSL-1) Genes in Heat-Induced Lateral Root Primordium Inhibition in Maize.
The Role of Promoter-Associated Histone Acetylation of Haem Oxygenase-1 (HO-1) and Giberellic Acid-Stimulated Like-1 (GSL-1) Genes in Heat-Induced Lateral Root Primordium Inhibition in Maize.
复制标题
血红素加氧酶 1 (HO-1) 和赤霉酸刺激的 Like-1 (GSL-1) 基因的启动子相关组蛋白乙酰化在热诱导玉米侧根原基抑制中的作用
DOI：
10.3389/fpls.2018.01520
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发表时间：
2018
影响因子：
5.6
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Zhang H;Yue M;Zheng X;Gautam M;He S;Li L
在植物中，侧根在吸收水分和养分方面起着至关重要的作用。玉米血红素加氧酶-1（ZmHO-1）和赤霉素刺激样蛋白-1（ZmGSL-1）等基因与侧根的发育有关。在本研究中，我们观察到热处理可能参与抑制玉米侧根原基（LRP）的形成，伴随着组蛋白3赖氨酸残基9（H3 K9）和组蛋白4赖氨酸残基5（H4 K5）的整体乙酰化水平的增加，表明组蛋白修饰与LRP抑制有关。然而，组蛋白去乙酰化酶（HDACs）抑制剂曲古抑菌素A（TSA），显然没有抑制LRP的形成，揭示了整体的超乙酰化可能不是热应激诱导的LRP抑制的决定因素。此外，在高温胁迫下，玉米侧根发育相关基因ZmHO-1和ZmGSL-1的表达下调，启动子区乙酰化水平降低，表明启动子相关的组蛋白乙酰化可能与热诱导玉米LRP抑制相关基因ZmHO-1和ZmGSL-1的表达有关。
In plants, lateral roots play a crucial role in the uptake of water and nutrients. Several genes such as Zea mays Haem Oxygenase-1 (ZmHO-1) and Giberellic Acid-Stimulated Like-1 (ZmGSL-1) have been found to be involved in lateral root development. In the present investigation, we observed that heat treatment might be involved in the inhibition of lateral root primordium (LRP) formation in maize, accompanied by an increase in global acetylation levels of histone 3 lysine residue 9 (H3K9) and histone 4 lysine residue 5 (H4K5), suggesting that histone modification was related to LRP inhibition. However, Trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), apparently did not inhibit the LRP formation, revealing that global hyperacetylation might not be the determining factor in the LRP inhibition induced by heat stress. Furthermore, expression of genes related to lateral root development in maize, ZmHO-1 and ZmGSL-1, was down-regulated and the acetylation levels in the promoter region of these two genes were decreased under heat stress, suggesting that promoter-associated histone acetylation might be associated with the expression of ZmHO-1 and ZmGSL-1 genes which were found to be involved in the heat-induced LRP inhibition in maize.
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影响因子：
5.2
作者：
Han, Bin;Xu, Sheng;Xie, Gui-Shui
通讯作者：
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影响因子：
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影响因子：
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影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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