Rehabilitation therapy for patients with glioma: A PRISMA-compliant systematic review and meta-analysis.
Rehabilitation therapy for patients with glioma: A PRISMA-compliant systematic review and meta-analysis.
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DOI：
10.1097/md.0000000000023087
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发表时间：
2020-11-06
期刊：
影响因子：
1.6
通讯作者：
Zhao N
中科院分区：
文献类型：
--
作者：
Zhao K;Yu C;Gan Z;Huang M;Wu T;Zhao N
胶质瘤是最常见的脑肿瘤类型，由于疾病本身的破坏性和治疗的副作用，患者往往会留下神经功能缺陷的症状。目前，康复治疗在胶质瘤患者中并不流行。目前还缺乏确切的证据来证明康复治疗对脑胶质瘤患者的益处。本次荟萃分析的目的是确定康复治疗是否能显着改善神经功能预后，提高胶质瘤患者的生活质量。应用计算机检索Cochrane、PubMed、Embase、Web of Science、Medline数据库1990-01/2020-05与脑胶质瘤康复治疗相关的文章。康复前为对照组，康复后为实验组。采用功能独立性测量(FIM)作为结果指数，包括总功能独立性、运动性功能独立性和认知功能独立性。使用STATA12.0进行荟萃分析。本研究共纳入8篇文章，共375例脑胶质瘤患者。Meta分析显示，康复后患者的神经功能得到明显改善，总体功能障碍(SMD = 0.96，95%CI = 0.66~1.26，P <； .001)、运动功能障碍(SMD = 0.75，95%CI = 0.54~0.96，P <； .001)和认知功能障碍(SMD = 0.35，95%CI = 0.19~0.50，P <； .001)均有明显改善。已发表的研究表明，康复治疗可以改善脑胶质瘤患者的功能预后和生活质量。今后应更加重视康复对脑胶质瘤患者的治疗价值。PROSPERO CRD42020188740。
Glioma is the most common type of brain tumor because of the destructiveness of the disease itself and the side effects of treatment, patients often leave symptoms of neurological defects. At present, rehabilitation treatment is not popular in glioma patients. There is a lack of definite evidence to prove the benefits of rehabilitation therapy for glioma patients. The purpose of this meta-analysis is to determine whether rehabilitation therapy can significantly improve the prognosis of neurological function and improve the quality of life of patients with glioma. The articles about rehabilitation treatment of glioma in Cochrane, PubMed, and Embase, Web of Science, and Medline database from January 1990 to May 2020 were searched. Before rehabilitation as the control group, after rehabilitation as the experimental group. The Functional Independence Measure (FIM) was used as the outcome index, including total FIM, motor FIM, and cognitive FIM. Use STATA12.0 for meta-analysis. A total of 8 articles were included in the study, with a total of 375 glioma patients. Meta-analysis of total FIM (SMD = 0.96, 95%CI = 0.66–1.26, P < .001), motor FIM (SMD = 0.75, 95%CI = 0.54–0.96, P < .001) and cognitive FIM (SMD = 0.35, 95%CI = 0.19–0.50, P < .001) indicated that the neurological function of rehabilitation was significantly improved in total, motor and consciousness. The published studies show that rehabilitation therapy can improve the functional prognosis and quality of life of glioma patients. More attention should be paid to the therapeutic value of rehabilitation for glioma patients in the future. PROSPERO CRD42020188740.