Improved survival of patients with metastatic breast cancer receiving combination chemotherapy. Comparison of consecutive series of patients in 1950s, 1960s, and 1970s
Improved survival of patients with metastatic breast cancer receiving combination chemotherapy. Comparison of consecutive series of patients in 1950s, 1960s, and 1970s
复制标题
接受联合化疗的转移性乳腺癌患者的生存率得到改善。
作者：
Michael B. Ross;A. Buzdar;T. Smith;N. Eckles;G. Hortobagyi;G. Blumenschein;E. Freireich;E. Gehan
对1956年1月（210例）、1966年1月（210例）和1975年1月（251例）连续登记在乳腺癌诊所的新诊断转移性乳腺癌患者组进行分析，以确定每十年使用的各种治疗方式对生存率的影响。比较预后特征相似的亚组患者的生存率。除了表现非常差的患者外，与前几十年相比，所有亚组在20世纪70年代的生存率都有显著提高。联合化疗被认为是提高生存率的主要因素。
Groups of patients with newly diagnosed metastatic breast cancer who were consecutively registered into a breast cancer clinic beginning January 1956 (210 patients), January 1966 (210 patients), and January 1975 (251 patients), were analyzed to determine the impact on survival of the various treatment modalities utilized in each decade. Comparisons of survival were made among subgroups of patients with similar prognostic features. Except for patients with very poor performance status, all subgroups showed a significantly improved survival in the 1970s compared with the earlier decades. Combination chemotherapy was considered to be the major factor in the survival improvement.