Engineering a material for biomedical applications with electric field assisted processing
Engineering a material for biomedical applications with electric field assisted processing
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DOI：
10.1007/s00339-009-5359-z
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发表时间：
2009-10-01
影响因子：
2.7
通讯作者：
Zhang, H. B.
中科院分区：
文献类型：
--
作者：
Ahmad, Z.;Nangrejo, M.;Zhang, H. B.
在这项工作中，我们使用多个共流演示了不同结构形态的纳米颗粒、液体和/或气体的原位封装，这些纳米颗粒、液体和/或气体也可以通过直接写入方法以指定的模式沉积，并且可以控制表面修饰以释放封装材料。将材料溶液暴露在外加电场中所提供的可能性范围可以产生大量的结构，这些结构可以容纳大量的生物医学应用，从微流体装置（微通道，装载各种材料），打印3D结构和图案，芯片上的实验室设备到用于药物输送和组织工程的封装材料（胶囊，管，纤维，密集的多层纤维网络）。以这种方式获得的结构可以在微米到纳米范围内变化，并且可以处理所有状态的物质。所展示的工作展示了一些处理生物材料的新结构和方法。
In this work, using multiple co-flows we demonstrate in-situ encapsulation of nano-particles, liquids and/or gases in different structural morphologies, which can also be deposited in a designated pattern by a direct write method and surface modification can be controlled to release encapsulated material. The range of possibilities offered by exposing a material solution to an applied electric field can result in a plethora of structures which can accommodate a whole host of biomedical applications from microfluidic devices (microchannels, loaded with various materials), printed 3D structures and patterns, lab-on-a-chip devices to encapsulated materials (capsules, tubes, fibres, dense multi-layered fibrous networks) for drug delivery and tissue engineering. The structures obtained in this way can vary in size from micrometer to the nanometer range and the processing is viable for all states of matter. The work shown demonstrates some novel structures and methodologies for processing a biomaterial.