Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study
Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study
复制标题
DOI：
10.1038/s41598-020-63511-9
复制
发表时间：
2020-04-16
影响因子：
4.6
通讯作者：
Jokisch, Martha
中科院分区：
文献类型：
--
作者：
Brachem, Christian;Winkler, Angela;Jokisch, Martha
睡眠特征与轻度认知功能障碍（MCI）的关系已在横断面研究中进行了研究，但很少在纵向研究中进行。在海因茨Nixdorf回忆研究（德国的一项基于人群的队列研究）的第一次和第二次随访中，对1,890名参与者的MCI事件和睡眠特征进行了评估（首次随访时年龄为50-80岁，平均随访时间为5.2年）。MCI通过广泛的认知测试进行评估。包括PSQI（匹兹堡睡眠质量指数）在内的睡眠问卷被用来评估睡眠质量、睡眠障碍、睡眠时间和卧床时间。在调整社会人口统计学和心血管危险因素的回归模型中评估暴露于睡眠特征时发生MCI的相对风险（RR）。睡眠质量差（PSQI>5）（RR=1.43，95%CI：1.12-1.82，完全校正，参考：PSQI
Associations of sleep characteristics with mild cognitive impairment (MCI) have been examined in cross-sectional, but rarely in longitudinal studies. Incident MCI and sleep characteristics were assessed in 1,890 participants of the first and second follow-up of the Heinz Nixdorf Recall study, a population-based cohort study in Germany (age at first follow-up 50-80 years, mean follow-up 5.2 years). MCI was assessed with extensive cognitive tests. Sleep questionnaires including PSQI (Pittsburgh Sleep Quality Index) were used to assess sleep quality, sleep disturbances, time asleep, and time in bed. Relative risks (RR) of developing MCI when exposed to sleep characteristics were assessed in regression models adjusted for sociodemographic and cardiovascular risk factors. Poor sleep quality (PSQI>5) (RR=1.43, 95% CI: 1.12-1.82, fully adjusted, reference: PSQI