Myocardial Hydroxyproline Reduced by Early Administration of Methylprednisolone or Ibuprofen to Rabbits with Radiation‐induced Heart Disease
Myocardial Hydroxyproline Reduced by Early Administration of Methylprednisolone or Ibuprofen to Rabbits with Radiation‐induced Heart Disease
复制标题
早期给予甲泼尼龙或布洛芬可减少放射性心脏病兔的心肌羟脯氨酸
DOI：
10.1161/01.cir.65.5.924
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发表时间：
1982
期刊：
影响因子：
37.8
通讯作者：
L. Whitesell
中科院分区：
文献类型：
--
作者：
W. Reeves;D. Cunningham;E. Schwiter;A. Abt;S. Skarlatos;M. Wood;L. Whitesell
在 57 只新西兰白兔中评估了甲基泼尼松龙 (MP) 和布洛芬 (IB) 减轻晚期辐射诱发心脏病严重程度的能力。在心脏照射之前和之后不久，15 只兔子接受了静脉注射。 MP，30 mg/kg，每天两次，持续 3 天，另外 15 名患者接受 IB，12.5 mg/kg，每天两次，持续 2 天。 14只照射兔子不给予任何药物，13只兔子作为对照既不照射也不给予药物。所有 15 只兔子均接受 MP 治疗，15 只兔子中的 13 只接受 IB 治疗，均存活了 100 天。未经治疗、接受辐射的兔子中只有七只活了那么久。每组接受治疗的兔子的寿命都比未经治疗、接受辐射的兔子要长（p < 0.01 和 0.05）。幸存的兔子在辐射后 100 天被处死。与未治疗、辐射组相比，治疗、辐射组的心包炎（p < 0.05）和心包积液（p < 0.01）发生率较低。每个受辐射组中至少有一些兔子有心肌纤维化的微观证据。通过测定心肌羟脯氨酸浓度（MHP）来定量纤维化。未经治疗、辐射的兔子中的 MHP 浓度高于那些用 MP (p < 0.05) 或 IB (p < 0.01) 治疗的兔子以及未经治疗、未辐射的兔子 (p < 0.01)。早期给予 MP 或 IB 可延缓心肌纤维化、心包炎和心包积液的发展，并提高辐射诱发心脏病实验模型的生存率。
The ability of methylprednisolone (MP) and ibuprofen (IB) to reduce the severity of the late state of radiation-induced heart disease was assessed in 57 New Zealand white rabbits. Before and shortly after cardiac irradiation, 15 rabbits received i.v. MP, 30 mg/kg twice daily for 3 days, and 15 others received IB, 12.5 mg/kg twice daily for 2 days. No drug was administered to 14 irradiated rabbits, and neither irradiation nor drugs were administered to 13 rabbits that served as controls. All 15 rabbits treated with MP and 13 of the 15 treated with IB lived for 100 days. Only seven of the untreated, irradiated rabbits lived that long. Longevity of each treated group of rabbits was better (p < 0.01 and 0.05) than that of the untreated, irradiated rabbits. Surviving rabbits were killed 100 days after irradiation. Pericarditis (p < 0.05) and pericardial effusion (p < 0.01) were less frequent in the treated, irradiated groups than in the untreated, irradiated rabbits. At least some rabbits in each irradiated group had microscopic evidence of myocardial fibrosis. The fibrosis was quantitated by determination of myocardial hydroxyproline concentrations (MHP). MHP concentration in the untreated, irradiated rabbits was greater than in those treated with MP (p < 0.05) or IB (p < 0.01) and in the untreated, unirradiated rabbits (p < 0.01). Early administration of MP or IB retarded the development of myocardial fibrosis, pericarditis and pericardial effusion, and improved survival in this experimental model of radiation-induced heart disease.