CYTO-TOXICITY OF LATEX URINARY CATHETERS
CYTO-TOXICITY OF LATEX URINARY CATHETERS
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DOI：
10.1111/j.1464-410x.1985.tb08992.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
ANDERSSON, LC
中科院分区：
文献类型：
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作者：
RUUTU, M;ALFTHAN, O;ANDERSSON, LC
心脏手术患者严重尿道狭窄流行后，对芬兰销售的所有品牌乳胶导管进行了细胞毒性研究，使用导管洗脱液。7个品牌中的4个品牌，包括狭窄病例中涉及的1个品牌，在使用30%导管稀释剂时，显示出显著的细胞毒性，并抑制各种人类细胞培养物中几乎所有细胞的生长。细胞DNA直方图显示，与有毒导管培养的DNA合成抑制。硅胶导管不影响细胞生长，这与用硅胶导管替换乳胶导管后未观察到新狭窄病例的发现相关。缺乏关于导尿管毒性的国际标准，导尿管质量控制不足。
After an epidemic of severe urethral strictures in cardiac surgery patients, all brands of latex catheters marketed in Finland were investigated for cellular toxicity with eluates made from the catheters. Four of the 7 brands, including the 1 involved in the stricture cases, showed marked cytotoxicity and inhibited almost all cell growth in various human cell cultures when a 30% catheter eluate was used. DNA histograms of cells cultured with toxic catheter eluate showed inhibition of DNA synthesis. Silicone catheters did not influence cell growth, which correlated with the finding that no new stricture cases were seen after the latex catheters were replaced with silicone ones. International standards regarding urethral catheter toxicity are lacking and that catheter quality control is insufficient.