Synaptic mitochondrial changes in the motor cortex following unilateral cortical lesions and motor skills training in adult male rats.
Synaptic mitochondrial changes in the motor cortex following unilateral cortical lesions and motor skills training in adult male rats.
复制标题
成年雄性大鼠单侧皮层损伤和运动技能训练后运动皮层突触线粒体的变化。
DOI：
10.1016/s0304-3940(02)01328-9
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
Jones,TheresaA
中科院分区：
文献类型：
--
作者：
Sakata,JonT;Jones,TheresaA
Unilateral lesions of the forelimb sensorimotor cortex and motor skills training interact to enhance synaptic plasticity in layer V of the motor cortex contralateral to the lesion in male rats. In this study, we assessed the metabolic correlates of these synaptic changes by quantifying the number and size of mitochondria in synaptic axonal terminals with perforated or non-perforated post-synaptic densities (PSDs) and single or multiple post-synaptic contacts. The number of synaptic mitochondria per neuron was significantly greater in rats with lesions. Neither manipulation affected mitochondrial size or number of mitochondria per synapse. Independent of experimental condition, terminals with perforated PSDs had more mitochondria than those with non-perforated PSDs and, among those with non-perforated PSDs, terminals with multiple synaptic contacts had more mitochondria than those forming single synapses.
