Afferents of vocalization-controlling periaqueductal regions in the squirrel monkey
Afferents of vocalization-controlling periaqueductal regions in the squirrel monkey
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DOI：
10.1016/j.brainres.2004.11.048
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发表时间：
2005-02-09
期刊：
影响因子：
2.9
通讯作者：
Jürgens, U
中科院分区：
文献类型：
--
作者：
Dujardin, E;Jürgens, U
为了确定中脑导水管周围灰质(PAG)发声控制区的输入，将麦胚凝集素-辣根过氧化物酶注射到6只松鼠(Saimiri Cerureus)的PAG部位，当注射谷氨酸激动剂同型半胱氨酸时，PAG处产生发声。对大脑进行扫描，寻找所有六种动物共有的逆行标记区域。结果表明，发声诱发部位接受广泛的输入，最重的投射来自周围的PAG、下丘脑背内侧和腹内侧、视前内侧区、黑质弥漫部、未确定带以及中脑、桥脑和延髓的网状结构。最大的皮质输入从额叶内侧皮质到达PAG。中等至弱的投射来自岛叶、外侧前额叶、前运动前皮质以及上、中颞叶皮质。皮质下中等至弱投射来自杏仁中央和内侧核、终纹核、隔核、伏核、视前外侧区、下丘脑外侧和后部、苍白球、顶盖前区、上丘深层、中央周围下丘、中脑三叉神经核、蓝斑、黑质致密部、中缝背侧和腹侧、前庭核、三叉神经脊束核、孤束核和薄束核。因此，中脑导水管周围发声诱发区的输入主要是边缘的、动机控制的传入；然而，输入也来自感觉、运动、唤醒控制和认知脑区。(C)2004爱思唯尔B.V保留所有权利。
In order to determine the input of vocalization-control ling regions of the midbrain periaqueductal gray (PAG), wheat germ agglutinin-horseradish peroxidase was injected in six squirrel monkeys (Saimiri sciureus) at PAG sites yielding vocalization when injected with the glutamate agonist homocysteic acid. Brains were scanned for retrogradely labeled areas common to all six animals. The results show that the vocalization-eliciting sites receive a widespread input, with the heaviest projections coming from the surrounding PAG, dorsomedial and ventromedial hypothalamus, medial preoptic region, substantia nigra pars diffusa, zona incerta and reticular formation of the mesencephalon, pons, and medulla. The heaviest cortical input reaches the PAG from the mediofrontal cortex. Moderate to weak projections come from the insula, lateral prefrontal, and premotor cortex as well as the superior and middle temporal cortex. Subcortical moderate to weak projections reach the PAG from the central and medial amygdala, nucleus of the stria terminalis, septum, nucleus accumbens, lateral preoptic region, lateral and posterior hypothalamus, globus pallidus, pretectal area, deep layers of the superior colliculus, the pericentral inferior colliculus, mesencephalic trigerninal nucleus, locus coeruleus, substantia nigra pars compacta, dorsal and ventral raphe, vestibular nuclei, spinal trigerninal nucleus, solitary tract nucleus, and nucleus gracilis. The input of the periaqueductal vocalization-eliciting regions thus is dominated by limbic, motivation-controlling afferents; input, however, also comes from sensory, motor, arousal-controlling, and cognitive brain areas. (c) 2004 Elsevier B.V All rights reserved.