The Endocardium and Heart Valves
The Endocardium and Heart Valves
复制标题
DOI：
10.1101/cshperspect.a036723
复制
发表时间：
2020-12-01
影响因子：
7.2
通讯作者：
Lincoln, Joy
中科院分区：
文献类型：
--
作者：
Dye, Bailey;Lincoln, Joy
心内膜细胞是一种特殊的内皮细胞，在胚胎发育过程中，它会在发育中的心脏内部形成一层膜，并在整个生命周期中保持这一膜。心内膜细胞是多种心血管系统的重要来源，包括冠状动脉内皮细胞、心内膜垫间充质细胞、心肌细胞、壁细胞、成纤维细胞、肝血管系统、脂肪细胞和造血细胞。导致这些血统的分化程序的变化具有有害的影响，包括过早死亡或出生时存在的重大结构畸形。在这里，我们将回顾有关心内膜细胞对瓣膜和非瓣膜谱系的贡献的文献，并强调这些过程所需的关键途径。胚胎(可能是成人)心内膜细胞的谱系分化潜能在损伤心脏组织的再生或心血管疾病的治疗方面具有治疗潜力。
Endocardial cells are specialized endothelial cells that, during embryogenesis, form a lining on the inside of the developing heart, which is maintained throughout life. Endocardial cells are an essential source for several lineages of the cardiovascular system including coronary endothelium, endocardial cushion mesenchyme, cardiomyocytes, mural cells, fibroblasts, liver vasculature, adipocytes, and hematopoietic cells. Alterations in the differentiation programs that give rise to these lineages has detrimental effects, including premature lethality or significant structural malformations present at birth. Here, we will review the literature pertaining to the contribution of endocardial cells to valvular, and nonvalvular lineages and highlight critical pathways required for these processes. The lineage differentiation potential of embryonic, and possibly adult, endocardial cells has therapeutic potential in the regeneration of damaged cardiac tissue or treatment of cardiovascular diseases.