Serum levels of P-selectin in men with high-functioning autism
Serum levels of P-selectin in men with high-functioning autism
复制标题
DOI：
10.1192/bjp.bp.107.043497
复制
发表时间：
2008-10-01
影响因子：
10.5
通讯作者：
Mori, N.
中科院分区：
文献类型：
--
作者：
Iwata, Y.;Tsuchiya, K. J.;Mori, N.
免疫功能障碍已被认为是自闭症谱系障碍的病理生理学机制。粘附分子的选择素家族在免疫/炎症反应中发挥着重要作用。我们通过酶联免疫吸附测定测定了 15 名高功能自闭症患者和 22 名年龄匹配的健康对照者中三种可溶性选择素（sP、sL 和 sE）的血清水平。患者中 sP-选择素和 sL-选择素的水平显着低于对照组。此外，sP-选择素水平与幼儿期社会发展受损呈负相关。
Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.