LOCALIZATION OF CALCIUM-ACCUMULATING STRUCTURES IN STRIATED MUSCLE FIBERS
LOCALIZATION OF CALCIUM-ACCUMULATING STRUCTURES IN STRIATED MUSCLE FIBERS
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DOI：
10.1126/science.147.3654.158
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发表时间：
1965-01-01
期刊：
影响因子：
56.9
通讯作者：
PODOLSKY, RJ
中科院分区：
文献类型：
--
作者：
COSTANTI.LL;FRANZINI.C;PODOLSKY, RJ
当青蛙肌纤维的肌膜已被解剖了，灌注钙溶液，然后用草酸盐，电子不透明的材料，可能是草酸钙，积累在肌浆网的终末囊。这些区域的钙积累与细胞内的钙汇，控制收缩-舒张周期的松弛阶段，其接近涉及细胞内刺激传导的小管表明，他们也可能是钙释放的区域，以触发收缩。
When frog muscle fibers from which the sarcolemma had been dissected away were perfused with a calcium solution and then treated with oxalate, electron-opaque material, probably calcium oxalate, accumulated in the terminal sacs of the sarcoplasmic reticulum. These regions of calcium accumulation were identified with the intracellular calcium sink that controls the relaxation phase of the contraction-relaxation cycle; their proximity to tubules implicated in intracellular stimulus conduction suggests that they might also be regions from which calcium is released to trigger contraction.