Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2
Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2
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DOI：
10.1039/c1pp05050h
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
George, Michael W.
中科院分区：
文献类型：
--
作者：
Cao, Qian;Creely, Caitriona M.;George, Michael W.
用瞬态可见光谱和红外光谱研究了fac-[Re（CO）（3）（F（2）dppz）（py）]（+）（F（2）dppz = 11，12-二氟二吡啶并[3，2-a：2 '，3'-c]吩嗪）与双链多核苷酸[poly（dA-dT）]（2）或[poly（dG-dC）]（2）结合后在皮秒和纳秒时域内形成的瞬态物种。后一种技术已被用于监测金属络合物和DNA，分别监测1900-2100和1500-1750 cm（-1）的区域。这些数据提供了直接的证据，电子转移从鸟嘌呤的金属络合物的激发态，这两个亚皮秒的时间尺度和寿命为35 ps的收益，可能是由于两个激发态的参与。[poly（dA-dT）]（2）复合物中未发现电子转移，尽管在DNA区域TRIR中观察到特征性变化，这与激发dppz复合物时嵌入位点中碱基结合的变化一致。
The transient species formed following excitation of fac-[Re(CO)(3)(F(2)dppz)(py)](+) (F(2)dppz = 11,12-difluorodipyrido[3,2-a:2',3'-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)](2) or [poly(dG-dC)](2) have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm(-1) respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)](2) complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.