Phenylbutyrate inhibits the invasive properties of prostate and breast cancer cell lines in the sea urchin embryo basement membrane invasion assay
Phenylbutyrate inhibits the invasive properties of prostate and breast cancer cell lines in the sea urchin embryo basement membrane invasion assay
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DOI：
10.1002/ijc.10609
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发表时间：
2002-10-10
影响因子：
6.4
通讯作者：
Ljungman, M
中科院分区：
文献类型：
--
作者：
Dyer, ES;Paulsen, MT;Ljungman, M
组蛋白去乙酰化酶抑制剂，如苯基丁酸酯，目前正作为潜在的抗癌药物进行临床试验。苯基丁酸盐可诱导多种肿瘤细胞分化和凋亡，并可与电离辐射和化疗协同作用诱导细胞凋亡。我们使用海胆胚胎基底膜侵袭实验表明，在临床可达到的剂量下，苯基丁酸盐能有效抑制前列腺和乳腺癌细胞的侵袭特性。这种抑制作用是剂量依赖性的，并且在药物被移除后至少持续24小时。这些结果表明，除了激活癌细胞凋亡外，苯基丁酸盐还可用于预防转移性疾病。(C) 2002 Wiley-Liss, Inc。
Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing radiation and chemotherapy to induce apoptosis. We used the sea urchin embryo basement membrane invasion assay to show that phenylbutyrate potently inhibited the invasive properties of both prostate and breast cancer cells at clinically achievable doses. This inhibition was dose-dependent and persisted for at least 24 hr after the drug was removed. These results suggest that in addition to activating apoptosis in cancer cells, phenylbutyrate may be used in prevention of metastatic disease. (C) 2002 Wiley-Liss, Inc.