Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve
Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve
复制标题
DOI：
10.1200/jco.2009.27.0827
复制
发表时间：
2010-10-10
影响因子：
45.3
通讯作者：
Kaufman, Peter A.
中科院分区：
文献类型：
--
作者：
Ahles, Tim A.;Saykin, Andrew J.;Kaufman, Peter A.
目的探讨年龄和认知储备对乳腺癌辅助治疗患者认知功能的影响。接受化疗的乳腺癌患者（60例，平均年龄51.7岁）在治疗前、治疗后1个月、6个月和18个月接受一系列神经心理学和心理测试。未接受化疗的患者（n = 72，平均年龄56.6岁）和健康对照者（n = 45，平均年龄52.9岁）以匹配的间隔进行评估。结果混合效应模型揭示了加工速度和语言能力领域的显著影响。对于处理速度，治疗组、年龄和基线认知储备之间的三方相互作用(P
Purpose To examine the impact of age and cognitive reserve on cognitive functioning in patients with breast cancer who are receiving adjuvant treatments.Patients and Methods Patients with breast cancer exposed to chemotherapy (n = 60; mean age, 51.7 years) were evaluated with a battery of neuropsychological and psychological tests before treatment and at 1, 6, and 18 months after treatment. Patients not exposed to chemotherapy (n = 72; mean age, 56.6 years) and healthy controls (n = 45; mean age, 52.9 years) were assessed at matched intervals.Results Mixed-effects modeling revealed significant effects for the Processing Speed and Verbal Ability domains. For Processing Speed, a three-way interaction among treatment group, age, and baseline cognitive reserve (P