Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children.
Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children.
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埃及农村儿童出生至 5 岁社区获得性丙型肝炎感染的发病率和危险因素。
DOI：
10.1016/j.trstmh.2010.01.009
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发表时间：
2010
影响因子：
2.2
通讯作者：
Strickland,GThomas
中科院分区：
文献类型：
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作者：
Saleh,Doa'aA;Shebl,FatmaM;El-Kamary,SamerS;Magder,LaurenceS;Allam,Alif;Abdel-Hamid,Mohamed;Mikhail,Nabiel;Hashem,Mohamed;Sharaf,Soraya;Stoszek,SoniaK;Strickland,GThomas
一项前瞻性研究，在三个埃及村庄（A，B和C）有一个高流行率的丙型肝炎病毒（HCV）感染检查社区获得性HCV感染的儿童发病率; 2852未感染的婴儿进行了前瞻性随访，从出生到5.5年。15例HCV抗体和/或HCV-RNA血清转化（发生率为0.53%）。10例同时具有抗-HCV和HCV-RNA; 4例仅具有抗-HCV; 1例在没有抗体的情况下具有HCV-RNA。所有年龄组的发病率为2.7/1000人-年（PY）。婴儿期为3.8/1000 PY，1-5岁年龄组为2.0/1000 PY。住院和出生体重低增加了感染的风险;而生活在村庄B，家庭具有较高的社会经济地位，和先进的母亲教育的保护。8名HCV感染婴儿中有6名报告了感染前的医源性暴露（例如住院治疗、治疗性注射、耳洞），而1岁以上儿童中只有2/7报告了这些暴露。有一个HCV阳性的母亲是唯一的其他报告的风险，在这些年龄较大的儿童。在随访结束时，6名（40%）儿童的病毒被清除。针对医源性暴露并关注风险因素的健康教育可以减少高危人群中儿童的丙型肝炎病毒感染。
A prospective study in three Egyptian villages (A, B and C) having a high prevalence of hepatitis C virus (HCV) infection examined incidence of community-acquired HCV infection in children; 2852 uninfected infants were prospectively followed from birth for up to 5.5 years. Fifteen seroconverted for either HCV antibodies and/or HCV-RNA (incidence of 0.53%). Ten had both anti-HCV and HCV-RNA; four had only anti-HCV; and one had HCV-RNA in the absence of antibody. The incidence rate at all ages was 2.7/1000 person-years (PY). It was 3.8/1000 PY during infancy and 2.0/1000 PY for the 1–5-years age group. Hospitalization and low birth weight increased the risk of infection; while living in village B, the family having a higher socioeconomic status, and advanced maternal education were protective. Six of eight HCV-infected infants reported iatrogenic exposures (e.g. hospitalization, therapeutic injections, ear piercing) prior to infection whereas only 2/7 children older than 1 year reported these exposures. Having an HCV-positive mother was the only other reported risk in two of these older children. The virus cleared in six (40%) children by the end of follow-up. Health education targeting iatrogenic exposures and focusing on risk factors could reduce HCV infection in children in high-risk populations.