Trends in childhood cancer incidence in the US (1992-2004)
Trends in childhood cancer incidence in the US (1992-2004)
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DOI：
10.1002/cncr.23169
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发表时间：
2008-01-15
期刊：
影响因子：
6.2
通讯作者：
Ross, Julie A.
中科院分区：
文献类型：
--
作者：
Linabery, Amy M.;Ross, Julie A.
背景资料。大多数儿科肿瘤的病因仍不清楚。对基于人群的发病率数据的检查提供了关于不同人口群体中的病因的洞察，并可能导致新的假说。目前这项研究的目的是提供有关美国儿童癌症发病率和趋势的最新信息，包括亚洲/太平洋岛民和拉美裔人口亚群，据作者所知，这些人的趋势以前从未被调查过。对国家癌症研究所监测、流行病学和最终结果(SEER)计划的13个登记机构获得的数据进行了评估，以评估1992至2004年间出生至19岁儿童中被诊断为常见原发癌症的发病率和趋势。结果：1992-2004年间，所有儿科癌症诊断病例的年平均发病率(APC，0.4%；95%CI，-0.1%-0.8%)略有上升，但无显著差异。白血病(APC，0.7%；95%CI，-0.1%-1.5%)，特别是急性淋巴细胞性白血病(APC，0.8%；95%CI，-0.4%-1.9%)有增加趋势，而中枢神经系统肿瘤总体上是稳定的(A-PC，-0.1%；95%CI，-1.1%-1.0%)；星形细胞瘤有2个连接点。肝母细胞瘤(APC，4.3%；95%CI，0.21%-8.7%)和黑色素瘤(APC，2.8%；95%CI，0.50%-5.1%)的发病率增加。不同人口学群体(性别、年龄和种族/民族)的差异也被描述。结论：观察到的趋势加强了基于人群的监测和进一步的病因学研究的持续需要。
BACKGROUND. The etiology of most pediatric neoplasms remains elusive. Examination of population-based incidence data provides insight regarding etiology among various demographic groups and may result in new hypotheses. The objective of the current study was to present updated information regarding childhood cancer incidence and trends in the U.S. overall and among demographic subgroups, including Asian/Pacific Islanders and Hispanics, for whom to the authors' knowledge trends have not been previously examined.METHODS. Data. obtained by 13 registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were evaluated to assess incidence and trends of common primary cancers diagnosed between 1992 and 2004 among children aged birth to 19 years. Frequencies, age-adjusted incidence rates, and joinpoint regression results, including annual percent change (APC) in incidence rates (and 95% confidence intervals [95% CI]), were calculated.RESULTS. Between 1992 and 2004, a modest, nonsignificant increase in the average annual incidence rate (APC, 0.4%; 95% CI, -0.1%-0.8%) was observed for all pediatric cancer diagnoses combined. There was a suggestion of an increase in leukemia (APC, 0.7%; 95% CI, -0.1%-1.5%), and acute lymphoblastic leukemia in particular (APC, 0.8%; 95% CI, -0.4%-1.9%), whereas rates for central nervous system tumors overall were stable (A-PC, -0.1%; 95% CI, -1.1%-1.0%); 2 joinpoints were observed for astrocytoma. Rate increases were noted for hepatoblastoma (APC, 4.3%; 95% CI, 0.21%-8.7%) and melanoma (APC, 2.8%; 95% CI, 0.50%-5.1%). Differences by demographic group (sex, age, and race/ethnicity) are also described.CONCLUSIONS. The observed trends reinforce an ongoing need for population-based surveillance and further etiologic studies.