TRPV3
TRPV3
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DOI：
10.1007/978-3-642-54215-2_11
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Zhu, Michael X.
中科院分区：
文献类型：
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作者：
Yang, Pu;Zhu, Michael X.
瞬时受体电位 vanilloid-3 (TRPV3) 是一种 Ca2+ 渗透性非选择性阳离子通道，广泛表达于皮肤角质形成细胞以及口腔和鼻上皮细胞中。 TRPV3 会被无害的高温和有毒的高温激活。皮肤角质形成细胞中 TRPV3 的激活会导致多种物质的释放，从而调节多种功能，包括皮肤屏障形成、毛发生长、伤口愈合、温度感知以及瘙痒和疼痛感知。虽然 TRPV3 的几种天然和合成配体已被描述，但其中只有一种，法呢基焦磷酸，是在动物细胞中自然产生的。结合遗传小鼠模型，这些化合物的应用不仅揭示了TRPV3通道的生理功能，还揭示了细胞外Ca2+、Mg2+和质子以及细胞内Ca2+-钙调蛋白、ATP、磷脂酰肌醇4,5-二磷酸、多不饱和脂肪酸、质子和Mg2+的调节机制。啮齿动物和人类中 TRPV3 的功能获得性基因突变有助于揭示该通道在皮肤健康和疾病中的关键作用。
Transient receptor potential vanilloid-3 (TRPV3) is a Ca2+-permeable nonselective cation channel widely expressed in skin keratinocytes, as well as oral and nasal epithelia. TRPV3 is activated by innocuous warm as well as noxious hot temperatures. Activation of TRPV3 in skin keratinocytes causes release of multiple substances, which in turn regulate diverse functions including skin barrier formation, hair growth, wound healing, temperature sensing, and itch and pain perceptions. While several natural and synthetic ligands have been described for TRPV3, only one of them, farnesyl pyrophosphate, is naturally produced in animal cells. Together with the use of genetic mouse models, applications of these compounds have revealed not only the physiological functions but also regulatory mechanisms of TRPV3 channel by extracellular Ca2+, Mg2+, and protons as well as intracellular Ca2+-calmodulin, ATP, phosphatidylinositol 4,5- bisphosphate, polyunsaturated fatty acids, protons, and Mg2+. Gain-of-function genetic mutations of TRPV3 in rodents and humans have been instrumental in unveiling the critical role of this channel in skin health and disease.