Antibacterial Properties of Magnesium In Vitro and in an In Vivo Model of Implant-Associated Methicillin-Resistant Staphylococcus aureus Infection
Antibacterial Properties of Magnesium In Vitro and in an In Vivo Model of Implant-Associated Methicillin-Resistant Staphylococcus aureus Infection
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DOI：
10.1128/aac.03936-14
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发表时间：
2014-12-01
影响因子：
4.9
通讯作者：
Dai, Kerong
中科院分区：
文献类型：
--
作者：
Li, Yang;Liu, Guangwang;Dai, Kerong
假体周围感染仍然是一种具有挑战性的临床并发症。我们研究了纯（99.9%）镁（Mg）在体外和体内植入物相关感染大鼠模型中的抗菌性能。镁对耐甲氧西林金黄色葡萄球菌诱导的骨髓炎非常有效，并改善了种植体周围新骨形成。还评估了细菌icaA和agr RNAIII转录水平，以表征Mg植入物抗菌特性的机制。
Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin- resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.